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THCA flower is changing how Americans experience cannabis—legally. It offers real effects with federal protection under the 2018 Farm Bill. In states without recreational marijuana, THCA flower has become the most powerful alternative. When heated, it becomes Delta-9 THC. This means smoking or vaping THCA gives you the same effects as traditional weed. But it’s technically legal—if sourced from compliant hemp.

At Black Tie CBD, we specialize in premium THCA hemp flower. Our flower is tested, clean, and grown indoors for quality. We offer award-winning strains, 30g ounces, and no excise tax. Plus, free shipping on orders over $100 and a 30-day satisfaction guarantee.

Let’s explore what THCA flower really is—and how to use it safely and effectively in 2025.

What Is THCA Flower?

THCA stands for tetrahydrocannabinolic acid. It’s the raw form of THC found in unheated cannabis and hemp. In its natural state, THCA is non-psychoactive. That means it won’t get you high unless it’s heated. When you smoke, vape, or bake THCA flower, it converts to Delta-9 THC. This process is called decarboxylation. That’s what makes THCA flower so exciting. You get all the benefits of marijuana—without violating federal hemp laws.

THCA flower looks and smells like weed. But it contains less than 0.3% Delta-9 THC before heating. That makes it legal to ship.

At Black Tie, we sell indoor-grown THCA flower that’s COA-verified and strain-specific. Each batch is tested for safety and compliance. This ensures you’re getting a clean, consistent, and federally legal experience with every puff.

How Is THCA Flower Made?

Creating high-quality THCA flower starts with the genetics. The plant must be bred for high THCA and low Delta-9 THC. Growers then cultivate the plant using indoor methods. This gives more control over light, airflow, and nutrients. At harvest, the flower is trimmed and slowly cured. This process locks in potency and preserves terpenes.

Curing also helps maintain the THCA in its acidic, non-psychoactive form until the user heats it. Once dried, the flower is lab-tested for THCA percentage and Delta-9 THC levels. Only batches under 0.3% Delta-9 pass compliance. Black Tie’s THCA flower is grown indoors, never infused or sprayed. Our strains are bred for natural potency and flavor.

We test every batch with third-party labs. These COAs confirm cannabinoid content and legal compliance. This means the THCA flower you receive from us is safe, federally legal, and packed with therapeutic potential.

Why Choose Black Tie for THCA Flower?

Not all THCA is equal. Many brands cut corners on growing, trimming, or testing. That’s where we stand apart. Black Tie only sells indoor-grown, non-infused THCA flower. Our buds are trimmed by hand, slow-cured, and terpene-rich. Each strain is selected for potency, flavor, and effect. From Lemon Cherry Gelato to Fruity Loops—we have a full genetic library.

We ship 30g ounces, not 28g, and never charge excise tax. That gives you more value and zero surprises at checkout.

Every flower product comes with a COA. These reports confirm that your flower is compliant and cannabinoid-rich. We also include usage guidelines so customers can enjoy each strain safely and effectively.

Top 5 Ways to Use THCA Flower

1. Smoking (Joints, Pipes, or Bongs)

Smoking is the most common way to use THCA flower. It instantly decarbs THCA into Delta-9 THC for fast, strong effects.

Roll your THCA flower into joints, load it into a glass pipe, or smoke it through a bong. This method gives you a full terpene profile. It also delivers the fastest onset of euphoria and body effects. Perfect for those who want classic cannabis-like experiences without legal risks.

2. Dry Herb Vaping

Dry herb vaporizers heat the flower without burning it. This method produces clean vapor and preserves delicate terpenes. It’s ideal for people with sensitive lungs or those who prefer smoother inhales.

Vaping THCA flower gives you rich flavor and controlled decarboxylation without combustion. It’s also more discreet—less smell, less irritation, and more efficiency per gram.

3. Decarbing THCA Flower for Edibles

To make edibles, you must first decarb THCA flower in the oven. Heating it activates the cannabinoids. Once decarbed, you can infuse it into butter, oil, or honey. Then use it in any recipe you like. This method gives longer-lasting effects. It’s great for those who prefer not to smoke or vape.

4. Glass Chillums or One-Hitters

For microdosing or discretion, one-hitters are a great choice. You use just a pinch of flower and get fast results.

Chillums offer a quick, pocket-sized way to enjoy THCA without rolling or vaping.

These tools are perfect for low-dose sessions or sampling new strains. They also help stretch your stash longer—ideal for daily users.

5. Mixing with CBD Flower

Want a more balanced experience? Blend your THCA flower with CBD-rich flower.
CBD can smooth out the high, reduce anxiety, and extend the session.

This mix offers an enhanced entourage effect—more cannabinoids working together for a fuller result.

It’s also a good method for newer users who want to ease into stronger effects.

Is THCA Flower Safe to Smoke?

Yes—if it’s clean, lab-tested, and sourced from a reputable vendor like Black Tie. THCA is not harmful in its raw form. When heated, it becomes THC—but it’s still safe to inhale in moderation. Just like traditional cannabis, smoke can irritate the lungs. Use glass, avoid combustion buildup, and stay hydrated. For more information visit our recent blog on, “Is THCA Safe Smoke?”

Always check COAs before buying. Never use untested or questionable flower. Black Tie’s THCA flower is third-party tested and grown indoors to eliminate contamination risk. We never spray, infuse, or artificially boost potency. What you see is what you smoke.

Is THCA Flower the Same as Weed?

It’s nearly identical—in every way that matters—once you heat it.

THCA flower looks, smells, and feels like marijuana. But it stays legal because it tests under 0.3% Delta-9 THC by dry weight. Once you apply heat, THCA becomes Delta-9 THC. That’s the same compound found in recreational cannabis.

So yes, it gets you high—just like weed. The difference is legal classification and source (hemp vs. marijuana). At Black Tie, we grow our flower to meet the same standards you’d expect from a top-shelf dispensary. Our strains offer real effects, stunning appearance, and exceptional terpenes—without the legal risk or retail taxes.

Does THCA Flower Smell Like Weed?

Yes. If you open a jar of Black Tie’s Lemon Cherry Gelato or Critical Mass—you’ll know it instantly. THCA flower is real cannabis in every way except for its Delta-9 content before heating. It carries the same terpenes, flavonoids, and aromas as traditional weed.

Depending on the strain, you may smell citrus, fuel, berries, skunk, or sweet pastry notes. The scent is potent—especially when fresh and properly cured, as all Black Tie strains are. If you're trying to stay discreet, store your flower in an airtight container. Use smoke filters or vapes for lower odor output.

Can I Legally Order THCA Flower Online?

Yes. THCA flower is federally legal to ship—if it’s derived from hemp and contains less than 0.3% Delta-9 THC by dry weight. That’s why Black Tie runs full-panel compliance testing on every batch. We ensure legal thresholds are never exceeded.

Our products come with Certificates of Analysis (COAs), confirming they’re Farm Bill–compliant and safe to ship nationwide.

However, laws can vary by state. Some states have introduced restrictions on smokable hemp or high-THCA products. Always check your local laws before ordering. At Black Tie, we also monitor legal updates to ensure safe shipping practices. If your state allows it, your THCA flower will arrive discreetly, promptly, and legally—via USPS Priority Mail.

Does THCA Flower Get You High?

Yes. Once heated, THCA turns into Delta-9 THC, the active cannabinoid responsible for the cannabis “high.” Smoking, vaping, or baking THCA activates it. The result is nearly identical to traditional marijuana effects.

Users report classic euphoria, uplifted mood, sensory enhancement, and appetite stimulation—depending on the strain. THCA flower won’t get you high if eaten raw. Only decarboxylation (heating) converts it into psychoactive form.

So yes—if you’re wondering whether THCA flower gets you high like weed: absolutely. It’s cannabis—just classified under hemp law.

How to Decarboxylate THCA Flower Properly

Decarbing THCA is easy. You just need an oven, a tray, and some parchment paper.

Step-by-Step Guide:

1.     Preheat oven to 220–240°F (105–115°C)

2.     Break your THCA flower into small pieces

3.     Place on parchment-lined baking tray

4.     Bake for 30–40 minutes

5.     Let it cool completely before using

This low, slow heat breaks off the acid (the “A”) in THCA and converts it to active Delta-9 THC.

Once decarbed, your flower is ready for infusion into oil, butter, tinctures, or capsules.
Store decarbed flower in an airtight jar in a cool, dark place for best potency.

🔥 Important: Don’t rush or overheat. Going too hot will burn cannabinoids and reduce potency.

FAQs About THCA Flower

Is THCA flower legal in all 50 states?

No. While it’s federally legal, some states restrict high-THCA hemp products. Always verify your local laws before ordering.

Is THCA flower stronger than Delta-8?

Yes. THCA converts to Delta-9 THC, which is more potent than Delta-8 THC. Expect stronger mental and physical effects.

How much THCA flower should I use?

Start small. One to two puffs is plenty for new users. Always wait 10–15 minutes before taking more.

What’s the best way to store THCA flower?

Keep it in a sealed jar, away from light and heat. This protects terpenes and potency for months.

Does THCA flower expire?

Not exactly. But potency and flavor degrade over time. Use within 6–12 months for best results.

Can I travel with THCA flower?

Within legal states—yes. Always keep it in original packaging with COA proof. Avoid carrying it across state lines.

Final Verdict: THCA Flower Is the Future of Legal Cannabis

THCA flower bridges the gap between traditional cannabis and federally legal hemp. It offers real effects, fast relief, and legal access.
With the right source, it’s safe, clean, and reliable—whether you smoke, vape, or cook with it.
At Black Tie, we offer the best THCA flower online—indoor-grown, lab-tested, terpene-rich, and shipped discreetly nationwide.
From Lemon Cherry Gelato to Critical Mass, our strains deliver award-winning quality and serious potency.

If you’re ready to explore legal cannabis without compromise, THCA flower is your next step.
And Black Tie is your trusted source.

By now, you should be aware of the new PhytoFacts® cannabis classification system that has been introduced for a more accurate measure of quality. If you aren’t aware of it, then go ahead and read our previous blog. This article aims to cover the OGs + Gas class and provide customers with a clear and concise roadmap.

What is the “OGs + Gas” terpene class?

As you can see, this class has a few notable qualities - specifically the fact that it is classified as a ‘hybrid’. Hybrids, or hybrid strains, were primarily known to contain Indica and Sativa genetics in the old classification system. Indicas, known for their effects on the body, and Sativas, known for their effects on the mind, can be combined to make a strain that provides physical and cerebral reactions. The best of both worlds, if you will. However, with the new classification system, there’s much more to it than just being a ‘hybrid’.

This class has been linked to tasting notes of gas, fuel, sweet, citrus, and pepper. The shifting codominance of limonene, myrcene and caryophyllene contribute to the overall effects that are said to be felt. The terpenes are the biggest contributor, which we will cover in our phytolab reports for our strains classified as OGs + Gas.

From the list of common cultivars are strains that we stock, and have tested with the updated system, as you can see below:

Strain 1: Chem Dawg

This strain is a standout among our customers. The medium-sized buds are dense and have a mix of bright and dark green tones. With a blend of green accented by dark reddish-orange hairs and a plenty of trichomes, the appearance differs slightly from that of hybrid or pure Indica lineage. The aroma is peppery, gassy, and deep and strong, akin to that of THC cannabis. Customers may feel their senses sharpen as this midday strain becomes more constructively intellectual and introspective in the proper environment. Chem Dawg (pronounced "kim") is a very social strain, perfect for catching up with friends while remaining calm and free of couch lock. Its ability to enhance sensory experiences also makes it ideal for creative projects. We recommend learning more here.

The dominant terpenes:

1. Myrcene: A terpene consistent with the OGs + Gas class is myrcene. Myrcene is known for its sedative, 'couch-lock' effects, myrcene helps calm the mind and body by boosting the production of mood-regulating neurotransmitters dopamine and GABA. It can also help relieve pain and relax muscles, which helps ease the bodily discomfort that often accompanies stress - which explains why this class is associated with relaxation.

Myrcene gives our cannabis strain a mildly sweet flavor profile and provides scent notes that are spicy, earthy, and muskiness - which can be seen in the report for ‘Chem Dawg’.

1. b-Caryophyllene: β-Caryophyllene is generally the most abundantly produced terpene in Nature. Over the last decade, it has gained scientific attention after discovering that it can directly activate cannabinoid receptors. Basically, the β-Caryophyllene terpene acts as a cannabinoid.
   
   In our Chem-Dawg strain, beta-caryophyllene most likely contributes to euphoric relaxation and creates the cozy, relaxed, happy mood often associated with some cannabis varieties - and specifically explains the uplifting feeling linked with the OGs + gas class.

1. Terpinolene: Terpinolene, a terpene dominant in about one in ten cannabis strains, is recognized for its woody smell combined with floral citrus notes, which explains the overall contribution to the ‘Chem Dawg’ strain having high citrusy attributes, and explains the link to the OGs + Gas classification.
   
   In our strain, terpinolene most likely contributes to cerebral stimulation and may create heightened energy and whizzing thought spirals often associated with some cannabis varieties. For some, this experience is positive, leading to further productivity and focus.

Minor Terpenes:

1. Beta-Pinene: In cannabis, two of the most important terpenes are alpha and beta-pinene. As the name suggests, these create a pine-like flavor and aroma and are found in massive concentrations in pine trees. This terpene is actually one of the contributors to the gas-like aroma of the overall class.

1. B-Ocimene: Ocimene is a terpene responsible for some of the sweet and herbaceous flavors of certain cannabis strains, and it can also add citrusy and woody undertones. It may also offer a wide array of medicinal properties and uplifting effects, consistent with the class.

Strain 2: Tahoe OG

This stunning Indica-dominant hemp strain is incredible, to say the least. The buds are medium in size and firm to the touch. A classic OG nose, covered with trichomes and releasing a harsh gassy fragrance. When you remove the lid from the jar, the smell is immediately noticeable, and it gets much better when you pinch the buds. The buds are sticky and fresh, with a CBDa content of over 16 percent. Providing a comfortable smoke with a smooth OG flavor in the beginning and a gassy finish. A small heaviness behind the eyelids and a noticeable mental influence are felt almost immediately. This strain is excellent for pain relief, stress reduction, and insomnia relief.

As you will find out from the report below, there aren’t as many high-concentrate terpenes as chem-dawg, but the strain still packs a punch. Get some Tahoe OG here.

The dominant terpenes:

1. b-Caryophyllene: As we have already described above, caryophyllene holds the trophy for the most flair out of the terpenes. The terpene caryophyllene is present in many herbs and spices, including black pepper, basil, and oregano, and cannabis strains with high levels of it deliver a spicy, funky warmth to the nose, similar to cinnamon and cloves.
   
   As you can see from the report, the strain being high in this terpene explains the spicy and citrusy tones as characteristic of the OGs + Gas class.

1. Limonene: Limonene is a terpene recognizable for its zesty citrus fragrance, primarily in lemon, but also in orange, lime, and grapefruit. Limonene is found in the peels of these citrus fruits and in many varieties of cannabis. Along with myrcene, limonene is one of the most abundant terpenes to occur in cannabis.
   
   Limonene is considered an uplifting terpene capable of creating a sense of euphoria. This is likely because the terpene modulates neurotransmitters in the brain, particularly serotonin. This links directly to the strong uplifting and euphoric feelings associated with the overall class.

1. Humulene: Formerly known as alpha-humulene or alpha-caryophyllene — was first identified in the essential oils of Humulus lupulus, commonly called hops, giving it a distinctive bitter “hoppy” taste.  It is also present in marsh elders and a wide array of herbs and spices, including; sage, basil, clove, black pepper, coriander, and balsam fir tree.
   
   Strains high in humulene tend to have a relaxing effect with a chance of couch-locking the user on top of boosting creativity, relieving pain, and calming the mind, which is consistent with the effects of the OGs + Gas class.

Minor Terpenes:

1. Linalool: Linalool is found abundantly in nature, and it is widely used for many purposes. It is known for its calming effect and ability to bring elevated stress levels to almost normal conditions. It is frequently used in perfumes, cosmetics, soap, and essential oils therapy. Several flavored beverage brands even use linalool as an all-natural flavoring.  
   
   Despite Linalool being a minor in this strain, the report shows how the calming effects and overall flavoring contribute massively.

1. Alpha-terpineol: or α-Terpineol, is terpene alcohol found in many natural oils such as pine and petitgrain (an oil from the bitter orange tree). It’s the most common terpineol isomer found in cannabis. This terpene complements its typical floral notes with a nice citrus-woody profile and lemon and lime nuances. It is excellent for citrus, tropical fruits, apple, tomato and coffee flavors.

As you should see from the lab reports, it’s clear how important each terpene is to a flower or strain's overall effects and classification. Not only do the terpenes contribute to the flavor profiles, but they stand to be the defining aspect of every class. This should go to show just how vital terpenes are, and why you should pay attention.

As you may have learned from our last blog, terpenes are the most overlooked yet arguably the most important aspect of cannabis. They’re a little bit like cannabinoids—THC, CBD, and others—in that they have specific and medically useful interactions with our bodies.

If you aren’t familiar with terpenes; unlike cannabinoids, terpenes are found in many plants; they’re the chemicals that give a plant its aroma and flavor. Different levels of terpenes in different strains of cannabis give it a more earthy, fruity, or skunky smell and taste. In addition to stimulating our senses, many of these terpenes have medicinal effects.

In the last several years, scientists started to speculate about the synergic and/or entourage effects of the other cannabis compounds. Today, in the first row are terpenes/terpenoids, but we’re also focused on talking about flavonoids, flavonoid glycosides, and polyphenols. There are 120 terpenes found in cannabis, but for the sake of time, this article will focus on the 5 most dominant terpenes found in cannabis.

So, what are the top 5 terpenes?

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One of the most common terpenes found in cannabis is myrcene (also known as alpha-myrcene or beta-myrcene). β-Myrcene is the most common and a particularly potent terpene and is a component of the hydrocarbon fraction of many essential oils. It occurs naturally in over 200 plants and is present in the emissions of many trees in different parts of the world. Exposure to β-myrcene from natural food sources is estimated to be 16,500 times more than from its synthetic use as a flavor substance.

On average, myrcene represents over 20% of the terpene profile in modern commercial strains, although individual samples vary widely in their terpene content.

Scents and Aromas

Myrcene has a spicy, earthy, musky scent that gives cannabis strains a mildly sweet flavor profile. β-Myrcene is a pleasant-smelling, olefinic, acyclic unsubstituted monoterpene that occurs naturally in many plant species, especially in the essential oils of plants such as hops, cannabis, lemongrass, verbena, and bay, as well as in citrus fruits and citrus juices.

Effects of Myrcene

Antioxidant Activity:

In recent decades, there has been growing interest in the use of naturally occurring antioxidants in food preservation. Antioxidant agents are accountable for preventing aging and degenerative diseases such as atherosclerosis, cardiovascular diseases, cancer, diabetes and neurological illnesses. They also have an important role in inhibiting lipid oxidation within food products.

Anti-inflammatory Activity:

Myrcene has shown anti-inflammatory and anticatabolic effects on human chondrocytes. Cartilage degradation and osteoarthritis progression was slowed down. The anti-inflammatory activity of β-myrcene may not only be credited to its antioxidant potential, but also with its interaction with signal pathway cascades involving cytokines and transcription factors.

Central Nervous System Effects and Neurobehavioral Activity:

In a study, Myrcene in cannabis demonstrated measurable effects on the autonomic nervous system in healthy human subjects. Inhalation of cannabis essential oil for 5 min improved nerve activity and was shown to relieve stress and anxiety, and the subjects generally felt more relaxed, energetic, calm, and elevated mood, five min post inhalation.

Black Tie Hemp Strains high in Myrcene:

• Blue Dream
• BubbleGum Special Reserve
• Sour Space Candy
• Suver Haze

Strain names commonly classified as indica, sativa, or hybrid can be found with high levels of myrcene, including popular sativa-dominant hybrids like Sour Space Candy and Blue Dream.

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Farnesene, also known as Trans-β-farnesene, is a sesquiterpene considered soothing for the mood with calming and sedative effects.  Farnesene is an umbrella term for six different sesquiterpenes which are all chemically similar. There are two types of farnesene: alpha (a) and beta (b), both of which are naturally-occurring in a variety of different plants.

Farnesene is an analog of farnesol and is found in various natural sources, including hops, ginger, turmeric, ylang-ylang, and German chamomile. Another intriguing effect of farnesene is that it acts in many plants as a natural insect repellent, functioning as a pheromone that interacts with various insects. Some studies have demonstrated that aphids release farnesene before the danger of death or when dying to warn their companions of the near threat.

Scents and Aromas

The terpene offers a number of notes, including sweet, woody, berry, fruity, and reminiscent of apples. In fact, that is what the smell reminds of - green apple. Whenever you feel these tones when smoking your fine cannabis, that would be Farnesene.

Effects of Farnesene

Antimicrobial Properties

In some studies, farnesene, in conjunction with other terpenes, has shown antimicrobial activity against some serious types of bacteria, such as Staphylococcus subtilis. Even though the research is limited in this area, using the terpene for this advantage in the human body is no doubt fascinating.

Anti-Cariogenic Properties

Certain types of bacteria in the mouth are directly responsible for causing the tooth enamel to break down and deteriorate. Because of the antimicrobial farnesene effects, terpene may help fight tooth decay. The terpene may be active against Lactobacillus acidophilus, one of the common culprits behind tooth decay.

Anti-Inflammatory Properties

Farnesene has been shown to have prominent anti-inflammatory properties. So much so, that the terpene has been used in the past in place of things like ibuprofen to ease everyday discomforts. The anti-inflammatory actions of the terpene may also be important for future studies in its ability to act against allergic responses.

Black Tie Hemp Strains high in Farnesene:

• Grandaddy Purple
• Apple Strudel

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If you’re a grower who appreciates cannabis with a great terpene profile, you may well have heard of beta-Caryophyllene. It is also known as ‘b caryophyllene’, β-caryophyllene or simply caryophyllene. Ever wondered what the difference is between beta caryophyllene and caryophyllene? There is no difference, they are just different names for the same terpene. It was one of the first cannabis-derived compounds other than THC, CBD, and CBN shown to bind directly to endocannabinoid receptors.

It was one of the first cannabis-derived compounds with a fundamentally different structure from the classical cannabinoids that interacts with the endocannabinoid system in humans. In many ways, beta-caryophyllene is an important reminder that terpenes and cannabinoids are not separate and that the two work in conjunction with one another.

Scents and Aromas

β-Caryophyllene is the primary sesquiterpene contributing to the spiciness of black pepper; it is also a major constituent of cloves, hops, rosemary, copaiba, and cannabis. It’s responsible for the slight bite of pungency associated with smelling cracked pepper.

Effects of Caryophyllene

Sleep

In combination with other terpenes, caryophyllene has shown promise as a sedative. A 2012 study published in the journal Pharmaceutical Biology found that mice treated with essential oil containing caryophyllene experienced increased sleep time as well as decreased locomotion and body temperature.

Beta-Caryophyllene Anti-Inflammatory Properties

Beta-caryophyllene can reduce inflammation in the brain and chemicals that cause oxidative stress associated with inflammation. These properties can aid the brain from swelling during a stroke and improve its outcomes. Besides, it has been shown to reduce gut inflammation.

Beta-Caryophyllene Antibacterial & Antimicrobial Properties

Studies suggest that beta-caryophyllene helps fight bacterial dental plaque build-up and is a potential alternative to prescribed medications like chlorhexidine. Also, it reduces microorganisms like Streptococcus pneumonia, Haemophilus influenzae, and E. coli.

Black Tie Hemp Strains high in B-Caryophyllene

• Chem Dawg
• Diamond Kush
• Pink Runtz
• Tahoe OG

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This sesquiterpenoid differs from other terpenes because of its unique structure. Guaiol, sometimes referred to as “champacol,” is most abundantly found in oily timber and resin of the tropical guaiacum plant. Moreover, the cypress tree is also known to be rich in this sesquiterpenoid and other conifers. Guaiol differs from many other terpenes—which are oil-based—because of its unique structure as a liquid.

It is a terpene that conveys an aroma of pine that features fragrant undertones of wood and rose. Like other terpenes, this medicinal molecule is produced by many plants other than cannabis, including cypress pine and guaiacum (an evergreen tree of the Caribbean and tropical America).

Scents and Aromas

Guaiol is responsible for the scents of many plants like nutmeg, tea tree, conifers, apples, cumin, and lilacs. It presents a refreshing piney and woody aroma with some undertones of rose in it. For this reason, guaiol is added to a large variety of foods and household items as an aromatic agent.

Effects of Guaiol

Antibacterial Activity:

A 2017 study entitled “The Essential Oil from the Fruits of the Brazilian Spice Xylopia Sericea A. St.-Hil. Presents Expressive In-vitro Antibacterial and Antioxidant Activity” and published in The Journal of Pharmacy and Pharmacology found guaiol to be effective in treating bacterial infections. The research revealed that this terpene may be useful as an antimicrobial ingredient in food preservation.

Cancer Potential:

A 2016 study entitled “Guaiol Regulates RAD51 Stability via Autophagy to Induce Cell Apoptosis in Non-small Cell Lung Cancer” that was published in the journal Oncotarget found that guaiol is an effective agent against cancer cells, resulting in their apoptosis, which is a form of genetically pre-programmed cellular death in which cancer cells basically kill themselves off.

Black Tie Hemp Strains high in Guaiol:

• Orange Cookies
• Grandaddy Purple
• BubbleGum S.R

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Terpinolene is one of the many terpenes in the terpinene and pinene family. While they all share the same molecular formula, weight, and construction,  the placement of the double carbon bond differentiates them. This defines their unique synergistic qualities for therapeutic benefits when combined with CBD products.

Besides showing up in many cannabis varieties, terpinolene is also found in turnips and turpentine. For a long while, research scientists believed terpinolene to act as a sedative. This was due to experiments that determined mice inoculated with terpinolene showed a great reduction in muscle motility contributing to sedation.

Terpinolene by any other name is still terpinolene. Because of its wide use, terpinolene is called by many names depending on the industry and application. Below are a few other names used for terpinolene which you may have encountered in many household products:

• δ-Terpinene (delta-Terpinene)
• 586-62-9 [RN]
• (±)-α-Terpinyl acetate

Scents and Aromas

Terpinolene, though, carries an array of smells you might find in cannabis: It’s piney, floral, herbaceous, and even a little citrusy. Like most other terpenes, terpinolene is produced by various other plant species, including apple, conifer, cumin, lilac, mint, nutmeg, parsnip, and tea tree.

Their extractions from plants are the most important components of the essential oils used in herbal medicine, nutritional supplements, and cosmetics. Terpinolene is used as an aroma agent in soaps and perfumes and as a component of some insect repellents.

Effects of Terpinolene

Sedative

A 2013 study showed sedative effects after nasal absorption into the body(Shimoadachi-cho, 2013). Additionally, In a previous study, the Journal of Natural Medicines tested the sedative effects of terpinolene-dense essential oils on mice. After they isolated terpinolene as one of its active ingredients, they then attempted to determine the structural reason why this terpene has sedative effects. Their research found “Comparison of terpinolene analog activities showed that a double bond in the side-chain or pi bonds in the six-membered ring play important roles in the sedative effect.”

Antimicrobial Activity

One study of a terpinolene-dense plant native to Iran states; “The antimicrobial activity of the essential oil was tested against three different bacteria by disc diffusion method and showed maximum inhibitory activity against Gram-positive bacteria, especially Bacillus subtilis.”

Antioxidant Activity

The International Journal of Phytotherapy and Phytopharmacology published a study where the preparation of LDL from human blood plasma enriched in terpinolene was isolated. The lipids of LDL were protected, and the proteins also didn’t experience oxidation, “This inhibition is due to a retarded oxidation of intrinsic carotenoids of LDL, and not, as in the case of some flavonoids, attributable to a protection of intrinsic alpha-tocopherol.”

Black Tie Hemp Strains High In Terpinolene

• Lemon Tree
• PineApple OG
• Chem Dawg
• Sour Space Candy

From the list of terpenes described, you should see the importance of terpenes in cannabis. They are not merely there for the scents and aromas, but they also have individual medicinal benefits worth considering. Cannabis is so much more than just a strain. Read more about how terpenes are gaining importance here.

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The days of an outdated and frankly inaccurate cannabis classification system are finally over. The market has blurred the lines between quality and craft cannabis for far too long - leaving customers and cultivators with no real roadmap to identify the range and spectrum of the medicinal possibilities contained within cannabis and the unique entourage effects possible from the diversity that it offers.

Experts consider Cannabis Indica, Sativa, and Hybrid the three main subspecies - the issue is that people have used the THC potency of strains to determine superiority. Measuring potency and the effects with this method is a long-outdated classification system, especially when it does not provide accurate labels for customers and budtenders alike. The words “Indica” and “Sativa” were introduced in the 18th century to describe different species of cannabis, but modern research has led to more information that we will share throughout this article.

Historically, this is how cannabis has been defined;

Strains

Cannabis Sativa

Sativa is supposedly uplifting and cerebral, enhancing creativity and productivity. Indicas provide what has been called a “body high,” while Sativa’s deliver more of a “mind high.” Unfortunately, Sativa plants require longer to grow and yield less medicine (flowers) than Indica varieties. Sativa’s smell sweet, fruity, or spicy. This difference in the aroma results from terpenes, the molecules within the plant that are cousins to cannabinoids like THC and CBD. While these chemicals sometimes provide stunningly pungent odors, their greatest benefit to patients is their medicinal efficacy.

The problem with the general ‘idea’ of what a Sativa does, is that there is no accurate spectrum representing an understandable visual for growers and customers to understand easily.

Cannabis Indica

The typical example of Cannabis Indica is a more compact, thick-stemmed bush than its cousins, usually reaching a height of fewer than two meters. The foliage is generally a dark shade of green, some examples appearing to have almost blue or green-black leaves. These leaves are composed of short, wide blades.

Most Indicas are supposedly a rich source of the cannabinoids THC, CBD, and CBN. While Cannabis Sativa often produces a higher proportion of THC than its other cannabinoids, Cannabis Indica usually contains significant levels of all three. Indicas tend to have more body-centered effects than Sativas – enhancing physical sensations, which is not accurately measured either.

Cannabis Hybrids

Typically, a Hybrid is a cannabis plant with Indica and Sativa characteristics. Because cannabis has been cultivated for centuries, most modern strains are hybrid. Pure Sativas and pure Indicas are rare, so most cannabis you'll find these days is a hybrid.

Hybrid strains typically develop either Sativa-dominant, Indica-dominant, or evenly balanced phenotypes. Strain descriptions usually list it that way or display the split as a percentage. Remember that the terms Indica and Sativa strains are most useful for cultivators in determining growth characteristics like how tall plants will grow or how long their flowering cycle will be. Effects share no apparent connection with today's cannabis plants' physical structure, hence why the classification system is largely outdated.

So why is this a problem?

According to SC labs (SC Labs is a company that offers comprehensive solutions for cannabis and hemp testing) co-founder, Josh Wurzer;

“The problem is that there is little standardization when it comes to defining and determining terpenes”

Measuring the superiority of cannabis is confusing, and frankly, the classification system is completely outdated. It no longer only comes down to the strain. The days of just searching out the highest THC totals are rapidly receding. Research has proven that terpenes are at the base of the entourage effect, where previously, it has been considered ‘minor’ information. Cannabis growers and breeders have been assigning labels to cultivars primarily based on aroma profiles and purported effects rather than genetic ancestry or overall chemical similarity. Cultivators, processors, retailers, and consumers could benefit from greater standardization when evaluating product quality and distinguishing label claims.

Because cannabis is a widely used substance increasingly being legalized for medicinal and recreational use, Cannabis’s genetic and chemical variation must be accurately quantified and communicated. Using strain labels like Sativa and Indica are used to describe a cultivar’s morphology, aromas and/or psychoactive effects. However, whether these labels capture meaningful information about Cannabis's genetic and chemical variation is incredibly unclear. This leaves room for inaccuracy and uncertainty in a world growing in popularity faster than any other industry.

In this study, the inaccuracy of reporting is clear;

“This is consistent with previous studies indicating that cultivar names were not reliable indicators of a sample’s genetic or chemical identity”

The study shows that the genetic structure of cannabis explained only 37% of the variance in labeling, meaning that Sativa–Indica labels do not accurately reflect genetic relatedness. When the study looked at the correlation of Sativa and Indica terpenes and cannabinoids, Sativa content was positively correlated with the concentrations of bergamotene and farnesene. While on the other hand, there were significant positive correlations between Indica labeling and three sesquiterpenes: guaiol, γ-eudesmol, and β-eudesmol. This shows that it goes far beyond mere classification, and it really comes down to far more than simple labels.

The contrasting aromas that have been associated with Sativa (that is, sweet) and Indica (that is, earthy) were key discriminators in a sensory evaluation of Cannabis cultivars and mediated customers’ perceptions of potency and quality.

What is the solution?

Simple; replace the three vague classes with six elaborate and detailed classifications instead. On February 16th, – SC Laboratories, Inc., (SC Labs) announced that it has licensed Napro Research LLC’s proprietary data visualization tool PhytoFacts®. Clients testing cannabis through the lab will now have access to this game-changing reporting format and algorithm that provides a visual profile of each strain’s chemical makeup. This new report format is intuitive and helps budtenders and consumers identify the right strain for their desired effect. As mentioned above, the terpene profile proves to be far more important than the breed of cannabis, which means that companies like SC Labs are putting an end to the days of simply seeking out the highest THC percentage. Science has converged to finally prove that terpenes are at the root of the entourage effect that consumers are seeking.

Always looking to level their playing field and eliminate as much bias as possible, SC labs' owners partnered with the event organizers of Emerald Cup and NAPRO research to help reframe the conversation regarding what defines “quality” in cannabis. The Emerald Cup is widely believed to be the World Series of Cannabis competitions as it is rooted in Humboldt County. The partnership is intended to help revolutionize the collective understanding of the true role of terpene content.

The new classification system focuses on sorting flower entries by primary terpene content, leveraging a combined decade of research into Cannabis phytochemistry between  PhytoFacts® coupled with a powerful database of over 250,000 terpene tests and aggregated by SC Labs, going back to their launch of terpene testing on Cannabis in 2013 as you can see below.

What are the new classes?

‘Jacks + Haze’ Class

• Mostly ‘Sativa’-leaning varietals
• Tasting notes – Fruity, Pinesol, Haze
• Effects – Energizing, Cerebral, Artistically Inspiring
• Common Cultivars – Classic Trainwreck, Jack Herer, Durban Poison, Super Lemon Haze
• Terpenes Profile: Terpinolene, Caryophyllene, Myrcene

‘Sweets + Dreams’ Class

• Mostly ‘Indica’-leaning varietals
• Tasting Notes – Fruity, Sweet, Woody, Hoppy, Herbaceous
• Effects – Relaxation, Couch Lock, Analgesic
• Common Cultivars – Blue Dream, Tangie, Forbidden Fruit, Grandaddy Purple, Purple Urkel, Grape Ape, Cherry AK, God’s Gift, Purple Punch
• Terpenes Profile: Myrcene, Pinene, Caryophyllene

‘Tropical + Floral’ Class

• Mostly ‘Indica’-leaning varietals
• Tasting notes – Sweet, Floral, Tropical Fruit
• Effects – Calming, Soothing, Relaxing
• Common Cultivars – Super Skunk, Hawaiian, In the Pines, Dream Queen
• Terpenes Profile: Ocimene, Myrcene

‘OGs + Gas’ Class

• True ‘Hybrid’ varietals
• Tasting Notes – Gas, Fuel, Sweet, Citrus, and Pepper
• Effect – Uplifting, Stimulating, Analgesic, Relaxation
• Common Cultivars – Classic OG Kush, Chemdog, Sour Diesel, Gorilla Glue
• Terpenes Profile: Any combination or shifting codominance of Caryophyllene, Limonene, Myrcene

‘Exotics’ (Rare Terpene Combinations) Class

• True ‘Hybrid’ varietals
• Tasting notes – varied based on chemistry of entry
• Effect – varied based on chemistry of entry
• Common Cultivars – rarest terpene profiles entered into the Emerald Cup Competition

‘Desserts’ Class

• True ‘Hybrid’ varietals
• Tasting Notes – Deserts, Doughs, Citrusy & Spicy
• Effects – Stimulating, Racy, Uplifting, Comforting
• Common Cultivars – Classic Bubba Kush, GSC, Gelatos, Cakes
• Any shift in codominance of Caryophyllene & Limonene

How We’re Using The New System

Because of the reliability and shift in the right direction, Black Tie CBD has made use of the latest testing for our ‘ChemDawg’ strain, as you can see below;

As you can see from the report produced by PhytoFacts®, there’s immense detail about the aroma & flavor, identifying the spectrum of profiles in depth. The particular aroma and tastes lean far more towards earthy with some sweet and fruity profiles. Similarly, the entourage effect is highlighted, giving the budtender or end-user a clear idea of its effects. The relaxation and comfort of the strain are highlighted, with lower energy levels. The report is easy to understand and interpret, and above all the classification is distinct without being confusing.

This goes to show how important terpenes really are, and how the entourage effect varies depending on multiple facets which are not usually shown - including highlights of b-Caryophyllene (3.943 mg/g), Myrcene (3.767 mg/g), Terpinolene (2.605 mg/g). The relevance of highlighting terpenes matters significantly because terpenes have also been identified as a new frontier in cannabis medicine. Until recently, the spotlight has been focused almost exclusively on the therapeutic qualities of cannabinoids, such as THC and CBD, but as our understanding of terpenes grows more sophisticated, it’s becoming apparent that these aromatic compounds are medicinal powerhouses too.

β-Caryophyllene: β-Caryophyllene is generally the most common sesquiterpene in cannabis, and the most abundantly produced terpene in Nature. Over the last decade, it has gained scientific attention after discovering that it can directly activate cannabinoids receptors. Basically, the β-Caryophyllene terpene acts as a cannabinoid.

This is the terpene that contributes to the ever-so-slight spicy flavor, but mainly to the earthy profiles as well as the relaxation quality of this strain.

Myrcene: Myrcene is the most abundant terpene in modern commercial cannabis. Myrcene has many therapeutic benefits. Like other terpenes, myrcene is believed to have potential anti-inflammatory, potential anti-tumor, sleep-supportive, and other health benefits.

Myrcene characteristically gives our cannabis strain a mildly sweet flavor profile and provides scent notes that are spicy, earthy and muskiness - and also contributes towards that relaxing and calm effect that was mentioned.

Terpinolene: Terpinolene, a terpene dominant in about one in ten cannabis strains, is recognized for its woody smell combined with floral citrus notes. In addition to its fresh aroma, terpinolene is known for its antifungal and antibacterial properties. Terpinolene is considered more multidimensional in comparison to other cannabis terpenes.

These combined effects and profiles of terpinolene are why there are more fruity aromas and comforting effects. The combination of all three highlighted terpenes should indicate the importance of a more accurate and science-backed classification system to ensure that all effects, aromas and profiles are accounted for.

Without having to handle the substance, users and budtenders can now have a true discourse about the desired flavor, fragrance, and potential effects of cannabis. Consumers may now finally buy cannabis online with ease thanks to the new classification system and PhytoFact® information.

Buying a CBD tincture can be an overwhelming process, especially when you’re faced with so many factors, like potency, spectrums, price, cannabinoids, and other considerations. Here at Black Tie CBD, we want to simplify the process and give you all the information that you need to make a confident decision in your purchase. We will be covering everything that you need to know.

Firstly, it’s important to highlight the spectrums and the purposes that they serve, so you know which one is best suited for your needs. The spectrum term indicates the number of other substances present in the CBD itself.  Even in plants containing very little THC (the psychoactive substance found in cannabis), there are many other chemicals present. These are other cannabinoids, terpenes, and flavonoids.

Full Spectrum vs Broad Spectrum:

If you are a user of CBD, then you have more than likely stumbled across terms such as “full-spectrum” or “broad spectrum”. The main difference between full-spectrum and broad-spectrum CBD is the compounds they contain.

If a CBD product contains several naturally occurring cannabis plant extracts, such as terpenes and other cannabinoids — including up to 0.3% THC — it is full-spectrum CBD.

Broad-spectrum CBD also contains several cannabis plant compounds, but it is typically entirely free of THC. All of the broad-spectrum items on BlackTieCBD.Net are completely THC Free.

Full Spectrum CBD:

Full Spectrum CBD contains the most naturally occurring extracts. This includes a small amount of THC (less than 0.3% THC Delta-9). There is certain scientific evidence of an ‘entourage effect’ – a positive response to the presence of various terpenes in CBD. Taking the full spectrum of terpenes, flavonoids, cannabinoids, fatty acids and trace THC is regarded by some scientists as the most effective way for the entourage effect to work.

Due to the “entourage effect”, full-spectrum CBD is believed to last longer and have more powerful effects than broad-spectrum or CBD isolate

Broad Spectrum CBD:

Broad-spectrum CBD oil is a middle ground between CBD isolate and full-spectrum CBD oils. It has all of the cannabinoids and other chemical compounds except for THC. It has all the beneficial chemical compounds except for THC, so you’re likely to gain some of the beneficial effects of the entourage effect.

Broad-spectrum also goes through the normal extraction process. For places where THC is illegal, the benefit of broad-spectrum CBD oil is that in the final stages of processing, the THC is removed from the extract. Therefore, broad-spectrum CBD oil will not show up on a drug test if the test is looking for THC.

If you're looking for a health boost from CBD but want to skip the THC effects, broad-spectrum is probably your best bet. If you don't mind THC and want to potentially get more benefits out of your CBD product, full-spectrum is probably the way to go.

Potency:

Now that you know which spectrum to choose, it all comes down to choosing the correct strength and potency. When searching for products, you’ll come across a lot of different strengths (potencies). You’ll find ranges from 300 mg to 4000mg per bottle. With so many CBD options to choose from it can make you feel like you have no idea what you’re even looking at. So let’s simplify it;

CBD potency specifically refers to how strong it is. On CBD oil labels, look for the milligrams per milliliter (mg/mL) - that’s what determines the product’s concentration of CBD. If a CBD extract is rated at 300mg, it’s going to be about half as strong (potent) as the same amount of a CBD extract rated at 600mg CBD. But, it also depends on the size of the bottle.

Here is another example where the bottle size is significant. Suppose there are two bottles of CBD oil; both have 300mg of CBD. However, one bottle contains 15ml of liquid, while the other has 30ml. In this case, the smaller 15ml bottle’s CBD concentration is double that of its 30ml counterpart with 20mg of CBD per ml against 10mg.

How to measure your dose:

A single dose of CBD Oil to be .5mL, and depending on the product, this can be easily measured using the marked dropper under the top.

To simplify it further, A 30ml bottle will contain 60 dosages within. If the potency of the bottle is 1200mg, each dose contains 20mg of CBD, while a 15ml bottle will contain 30 dosages within. If the potency of the bottle is 1200mg, each dose contains 40mg of CBD. This should act as your guideline when choosing your dosage, and fortunately we released our tinctures in these specifications to make it easier for our customers.

For example:

Low-potency CBD oil (300 mg)

This is a relatively low-potency oil and is a good option for individuals who are just starting out or who may be sensitive to CBD. A low-strength 300 mg bottle is a good option to take as a daily supplement. Many people take a single daily dose of it for boosted general health, and also to help lower stress levels.

Mid-Potency CBD Oil (600mg)

A 600 mg CBD oil is a good “step-up” option for people who find they’re having to take large (and/or multiple) doses of lower potency. In general, a lot of people use products in this strength range for things like anxiety and day-to-day pain.

High-Potency CBD Oil (1200mg +)

The 1,000 mg range is closing in on the higher end of the potency scale, but some bottles could range to 5000mg and above, with the intention of higher potency in fewer drops. Products in this strength range are commonly used for sleep issues, deep muscle soreness, migraines, and day-to-day stress and anxiety.

So, which one should you choose? As much as we would love to answer that for you, each person is different. A great way to make your choice is to ask yourself why you want to take CBD in the first place and assess which potencies are typically used for those reasons.

Another aspect to consider that not many people pay attention to, but should, is the Cannabinoid used or the combination thereof.

Cannabinoids and combinations:

Cannabinoids are like a buffet to choose from. Choose the ailments you suffer from, and select the product that contains the helpful cannabinoid compounds that work best for you. Most people select CBD as it is the most popular and widely known cannabinoid, which doesn’t necessarily mean that it is the answer to all of your needs.

CBD:

CBD is generally great for overall well-being. It is suitable for general ailments and issues that you might be facing in your life. Over the last few years, CBD has become the cannabinoid of choice, not only for the many therapeutic benefits it offers, but also because it has no psychoactive properties. Unlike THC, CBD offers pain relief and other benefits without the risk of paranoia, anxiety, or impaired cognitive function.

This means that CBD is great for people wanting to target a number of ailments and use it for general health purposes.

CBG:

CBG interacts with the body in a different way. This means it has different effects than CBD does.  It is thought that CBG has a calming effect on the body, causing a relaxation of the nerves. There are technical terms for such changes, for example, inhibition of the sympathetic nervous system but rather than be blinded by complex medical terms it is easier to think of CBG as having a nice calming effect. CBG also appears to increase the levels of our natural, in-built cannabinoid called anandamide. This wonderful endogenous cannabinoid quite simply makes us feel good.

This means that CBG is most suitable for people striving for that ‘feel good’ feeling, or the general serenity within the body.

Delta-8:

Like delta-9 THC, delta-8 produces feelings of euphoria, relaxation, and potential pain relief, but they’re a lot milder. For people who don’t want to experience a pronounced “high,” the lower potency may be a benefit. Because of this, Delta 8 can be used to treat a wider range of cancer patients, such as those who won’t use Delta 9 THC because of the anxiety feeling they receive when they take it.

This makes Delta-8 a great sedative and the perfect candidate for people dealing with more intense ailments, but still offers a wide use for overall well-being, too.

With all of that being said, choosing your tincture comes down to three main factors; Spectrum, potency and strength, and finally the cannabinoid or combination of cannabinoids. From this, you should be able to understand and choose the product that best suits your needs. At first glance, it seems to be an overwhelming process, but really it’s quite simple.

Have a look at our selection of tinctures for one that best suits your needs.

The cannabis plant is home to over 200 cannabinoids and terpenes that have potential health benefits. Following the wild success of delta 8 THC as a legal alternative to the more controlled availability of delta 9 THC, the cannabis industry has sought other less-known cannabinoids to compete in the diverse cannabis marketplace. One of the newest, semi-synthetic cannabinoids called hexahydrocannabinol, usually shortened to HHC.

Hexahydrocannabinol (HHC) is a cannabinoid that was first discovered in the mid-1940s. In 1944, the American chemist Roger Adams created HHC when he added hydrogen molecules to Delta-9 THC. This process is known as "hydrogenation." HHC is found in limited quantities in the hemp plant. Although HHC is a naturally occurring compound, it is hard to obtain sufficient amounts to make products. But by certain production processes, companies can convert CBD into HHC to make a wide variety of products.

While HHC has been around for years, it has not been often discussed by cannabis users until recently.. HHC is a minor cannabinoid; it occurs naturally in cannabis, but in amounts too small to make extraction cost-effective - this means that for companies to sell this cannabinoid, they’re going to need to make it in a lab. HHC does, however, have one major legal advantage over delta 8 and delta 10: it isn’t THC.

So how is HHC made?

As mentioned above, Roger Adams is the first person to discover HHC using the process known as ‘hydrogenation’. There are a couple of different methodologies to hydrogenate delta-8 into HHC, but Hydrogenation is simply treating a compound with hydrogen, which causes a chemical reaction between hydrogen and another compound or element, usually in the presence of a catalyst such as nickel, palladium, or platinum. This is done in order to reduce or saturate organic compounds.

Adams originally applied this technique to THC derived from marijuana plants, but since the 2018 Farm Bill came into effect, legalizing cannabis crops with less than 0.3% delta-9 THC, more manufacturers are applying the hydrogenation of cannabinoids to CBD to produce HHC.

When it comes to HHC specifically, Hydrogenation modifies the structure of delta 9 THC by replacing a double bond with two hydrogen atoms, which changes its molecular weight and makes it more stable. According to chemist Mark Scialdone;

“A major benefit to hydrogenation is that it offers stability at the molecular level, assisting with both shelf life, and resistance to heat.”

It should be said, though, that the acronym “HHC'' is also used in scientific literature to refer to dangerous synthetic substances like 9-Nor-9β-hydroxyhexahydrocannabinol and 11-Nor-9β-hydroxyhexahydrocannabinol. All those Greek letters and super-long hyphenated chemical names are surefire signs that these forms of HHC are synthetic.

What Are The Effects Of HHC?

First, it’s important to note the different types of HHC that are available on the market. There are at least 10 types of HHC:

1. HHC — Hexahydrocannabinol (CAS# 6692-85-9)
2. 7-OH-HHC — 7-hydroxyhexahydrocannabinol (CAS 64663-39-4)
3. 8-OH-iso-HHC — 8-hydroxy-iso-hexahydrocannabinol (No CAS#)
4. 9α-OH-HHC — 9α-hydroxyhexahydrocannabinol (CAS# 52171-85-4)
5. 7-9α-OH-HHC — 7-oxo-9α-hydroxyhexahydrocannabinol (No CAS#)
6. 10α-OH-HHC — 10α-hydroxyhexahydrocannabinol (No CAS#)
7. 10α-ROH-HHC — 10aR-hydroxyhexahydrocannabinol (No CAS#)
8. HU211 — 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol (CAS 112924-45-5)
9. HU243 — 11-Hydroxy-3-(1′,1′-dimethylheptyl)hexahydrocannabinol (CAS 140835-14-9)
10. HDHHC — 3-Dimethylheptyl-11-hydroxyhexahydrocannabinol (CAS 140835-18-3)

HHC has very similar effects to delta-9 THC—it's a psychotropic compound that produces feelings of euphoria, changes in perception, altered cognition, as well as other potential properties. When it takes on other forms, it becomes slightly more complicated. Many users report the effects of HHC are similar to that of delta 8 THC in terms of being more heavily weighted towards relaxation than stimulation. HHC is more potent than delta 8 but slightly less potent than delta 9 THC.

We've seen a sudden ride of THC isomers—variants of the notorious delta-9 THC molecule, as people look for a legal means to experience the intoxicating effects of marijuana. Popular THC cannabinoid analog isomers include delta-8 THC and delta-10 THC derived from hemp crops. Although HHC isn’t technically a THC, it does produce similar effects—if you use enough of it. When it’s produced in the lab, an HHC batch is a mix of active and inactive HHC molecules. The active HHC binds well with your body’s cannabinoid receptors; the others don’t.

A study published in 2010 found that HHC’s effects lasted a long time in rats. Overall, apart from the limited research outlined in this section, there is nothing else to link HHC with the benefits claimed by manufacturers. Certainly, there are no studies on humans that provide any insight.

Is HHC Legal?

Although HHC is not the same as THC, it is potentially illegal if deemed synthetic. The FDA’s Interim Final Rule (IFR) states that synthetic cannabinoids in hemp are illegal, while naturally-occurring ones are permitted. It is true that HHC occurs naturally in hemp and cannabis but only in tiny amounts. HHC manufacturers make it in a lab via a chemical process designed to create more of it.

With the rise of delta 8, hexahydrocannabinol was recognized as yet another form of “legal THC” capable of being sold to the masses. No matter how much marketing material you read, however, delta 8 and HHC will never be equitable. One is a synthetically derived cannabinoid while the other is a natural substance.

We wouldn’t be surprised if HHC starts getting attention from the DEA, as we suspect that considering the need to synthetically create it - HHC falls under the Federal Analogue Act, which automatically classifies analogs of Schedule 1 drugs as Schedule 1 drugs themselves. If the DEA agrees, HHC could have a very short market span.

Is HHC Safe?

As it stands, HHC is rarer and more difficult to derive than delta 8, the HHC market is smaller and less competitive, resulting in comparatively inferior products. Because hexahydrocannabinol (HHC) is still very new, there aren't very many studies available that investigate its potential effects and safety - which is enough to tell us that as it stands, it is not particularly safe.

With the limited research on HHC, we highly suggest that you stick to the better known cannabinoids with ample research surrounding it like CBDV which we have done extensive research into and offer safe, legal products containing this cannabinoid.

HHC seems to be following a very similar and dangerous route to THCO, another synthetic cannabinoid taking the industry by storm. We can only hope that the search for something stronger and different does not take priority over the search for something more beneficial and well-researched.

With Covid-19 impacting us for the last two years, the world is rapidly searching for ways that we can effectively manage the virus, despite the variants that constantly pop up. Finally, it seems that research is progressing and it’s the cannabis industry at the forefront of the latest research advancements by researchers affiliated with Oregon State University. These researchers conducted a study that suggests that cannabis compounds prevent Infection by the Covid-19 Virus.

The COVID-19 pandemic includes at least 272 million cases worldwide, 5.3 million deaths, and over 600 000 new cases daily. While the rollout of vaccines is underway, the rapid spread of COVID-19 underscores the need for new treatments.

Background Information:

In January 2021, this study looked into the possibility that cannabis may offer some help for patients with COVID-19. The study looks at one of the primary biological events that occur in patients with severe acute respiratory distress cases from COVID-19, something called a “cytokine storm.”

C.Sativa, a type of cannabis, was found in a cytokine storm study to reduce multiple cytokines and pathways related to inflammation and fibrosis. Two of the cytokines that C.Sativa reduced were TNFa and IL-6, which are thought to be the main targets when trying to block a COVID-19 cytokine storm and acute respiratory distress syndrome.

In another study done in September of 2020 on mice, they found the following;

“Several reports demonstrated that cannabidiol (CBD), a phytocannabinoid produced by the cannabis plant, can block IL-6 in several models of inflammatory diseases.”

What do the studies say in 2022?

A report on the research, “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants,” was published online on January 10th, 2022 by the Journal of Natural Products.

COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Researchers have found that the viral spike protein of SARS-CoV-2 to the human cell surface receptor angiotensin converting enzyme-2 (ACE2) is a critical step during the infection of human cells. The researchers looked into the following possibility:

“Therefore, cell entry inhibitors could be used to prevent SARS-CoV-2 infection as well as to shorten the course of COVID-19 infections by preventing virus particles from infecting human cells.”

Researchers discovered that cannabinoids increase the cell’s response to several key proteins produced by the coronavirus genome, which is an effect that had not been discovered prior to the study. Researchers also looked at how the proteins from the genome operated in human kidney cells and healthy control cells, both with and without cannabinoids.

Cannabis and its effectiveness against new variants:

The spike protein is the same part of the virus targeted by Covid-19 vaccines and antibody therapies. In addition to the spike protein, SARS-CoV-2 has three more structural proteins as well as 16 nonstructural proteins and several compounds van Breemen characterized as “accessory” proteins, all of which are potential targets for drugs developed to prevent Covid-19.

The two compounds commonly found in hemp - called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA - were identified during a chemical screening effort as having potential to combat coronavirus. In the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, they found that cannabinoids bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people, stating that;

“Cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells”

This means that cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.

The study then goes on to state that the most important piece of evidence found was that CBGA and CBDA were equally as effective against the alpha and beta variants. The abstract ends off on a highly positive note, expressing that cannabinoids do in fact have the potential to prevent and likely treat infection by SARS-CoV-2.

What other benefits could cannabis pose for Covid-19?

• Pain
  As we have discussed in previous articles, cannabis offers potential benefits for things like pain, anxiety, and other ailments. With symptoms of COVID-19, including body aches, sore throat, and headaches, pain relief would be welcome by many patients.
  
  As it currently stands, Medicinal cannabis registries typically report pain as the most common reason for use. In this study, the conclusion came to the fact that looked at multiple ailments being treated with cannabis, going on to state the following:
  
  “Headache was then evaluated as a primary symptom being treated by medicinal cannabis “

1. Anxiety
   The number of people reporting high levels of anxiety has sharply elevated during the coronavirus (COVID-19) pandemic. The factors most strongly associated with high anxiety during the pandemic include loneliness, marital status, sex, disability, whether someone feels safe at home or not and work being affected by the coronavirus (COVID-19) pandemic.
   
   There is understandable concern about the impact of the pandemic on people’s well-being. Fortunately, though, compounds within cannabis have shown impressive anxiety-reducing qualities, particularly CBD, which has been shown in studies to increase serotonin activity and lower cortisol levels.

Is Cannabis safe to consume for Covid-19 patients?

While most people consume cannabis by smoking it, it is not the only way to consume it. Companies like ourselves offer multiple variations of consumption like edibles, tinctures and more that have very low THC, yet still offer the same benefits.

After the last two years of uncertainty, illness and chaos due to the pandemic, it’s relieving to see that cannabis has shown a lot of potential in fighting against COVID-19 and could potentially offer new solutions to tackle the pandemic.

Where can you get CBDA and CBGA products from?

The team here at Black Tie CBD is relieved and grateful that we’re a part of an industry that is helping to better global health in such an impactful way. As a company, we've seen the value in CBDA products and we've just released our brand new CBDA isolate so you can keep safe too.

It’s a new year, and with the new year comes new laws that are to take effect, and for the cannabis and vape industry - these laws may not be as promising for the future of the industry. We’ve seen several states take a stance against vaping specifically, and added to the list are Illinois and Oregon. This article will cover everything you need to know about what this means for the vape community in these states moving forward.

Illinois

As of January 1st, 2022, the state of Illinois has passed a new bill, namely Illinois Senate Bill 00512 - The “Preventing Youth Vaping Act” which was sponsored by Sen. Julie Morrison and Rep. Bob Morgan. This bill is as the name suggests; a bill that creates additional restrictions and regulations on e-cigarettes, aiming to prevent vaping by children. So, what does this act mean for Illinois?

First of all, the law defines an e-cigarette as;

• A device using a battery or other mechanism to heat a solution, resulting in vapor for inhalation.
• Any container of a substance that is intended to be used in the device or used to refill the device.
• Any substance that is intended for use in the device.

According to the Illinois attorney general, the act is intended to do the following;

“Address the epidemic levels of youth e-cigarette usage by prohibiting companies from marketing products to minors.”

The state has clearly stated its interest and belief in encouraging the youth to live vape-free. While vaping is a controversial topic in regards to health, the state has a strong stance in stepping towards keeping these products out of the hands of anyone younger than 21 years old. This bill, however, also poses a challenge to the industry by limiting companies from directing their advertising and marketing.

While most people may stand by the age-restricted purposes of this bill, this legislative change poses nuanced difficulties to companies that offer these products and results in fines of up to $25,000 as well as a 1-3 year prison sentence if found guilty. The bill complicates marketing these products by stating the following rules:

1. Companies can not market vape products as modified risk tobacco products
2. Companies can not market a vape product as providing smoking cessation benefits unless approved by the FDA.
3. Companies can not market vape products in a way that appeals to or encourages any person under the age of 21 to use them.

As online tobacco and e-cigarette sales continue to grow, the new law and restrictions as listed above seek to prevent minors from purchasing e-cigarettes by requiring online retailers to take steps to ensure that purchasers are at least 21 years old. The state goes as far as urging the FDA to ban flavored tobacco products and to strengthen e-cigarette guidance by prioritizing enforcement actions against flavored e-cigarettes.

The only exception currently stands for the following;

“Electronic cigarettes first sold prior to August 8, 2016 and for which a premarket tobacco product application was submitted to the U.S. Food and Drug Administration by September 9, 2020”

e-cigarettes that utilize synthetic (tobacco-free) nicotine or CBD-containing e-cigarettes, for example, that arguably are not tobacco products under federal law, would not be considered adulterated in Illinois for not having authorized PMTAs.

Oregon

As of January 1st, 2022, the state of Oregon passed House Bill 2261 which prohibits remote sales of inhalant delivery systems. This new legislation prevents any businesses involved in selling vape products from shipping or mailing any products that may have been purchased online or by other distant means. This means that the only sales permitted are in-person sales.

These restrictions do not, however, apply to freight forwarders or motor carriers. Apart from that exception, no retailers or businesses may sell smokable tobacco products unless the purchase was made face-to-face.

‘Inhalation delivery systems’ refers to anything that is one of the following;

“A device that can be used to deliver nicotine in the form of a vapor or aerosol to a person inhaling from the device; or a component of a device described in this paragraph or a substance in any form sold for the purpose of being vaporized or aerosolized by a device described in this paragraph, whether the component or substance is sold separately or is not sold separately.”

According to that description, the following products fall into the Oregon HB 2261 Shipment ban:

• Bottled e-liquid (with or without nicotine)
• Closed-system ENDS (e.g. pod/cartridge or disposables) pre-filled with non-nicotine and nicotine-containing e-liquids
• Open-system devices
• Open-system/Open-tank ENDS device

This means that the legislation appears to restrict the DTC sale of most types of vapor products.

The implementation of this bill was put forward due to the FDA reporting that 3.6 million middle and high school students were current users of e-cigarettes In 2020. While the FDA finalized a rule in 2016 that included ENDS in the definition of a tobacco product, the majority of regulation of these products is left to the states. Supposedly, despite the current regulations that were passed in 2017 - the state insisted that the regulations still make it relatively easy for minors to obtain products online.

A device is considered adulterated if:

1. It consists of any poisonous, deleterious or filthy substance that may render injuries to health.
2. It is held or packaged in containers composed of any poisonous or deleterious substance.

Considering these new legislations, it is clear that further restrictions are being imposed on the states around the U.S. and pose challenges to the vapor industry. While these new bills are proposed to provide a safer environment for minors, it should be asked whether this is a step forward or a step backward in the industry.

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