CBD

The days of an outdated and frankly inaccurate cannabis classification system are finally over. The market has blurred the lines between quality and craft cannabis for far too long - leaving customers and cultivators with no real roadmap to identify the range and spectrum of the medicinal possibilities contained within cannabis and the unique entourage effects possible from the diversity that it offers.

Experts consider Cannabis Indica, Sativa, and Hybrid the three main subspecies - the issue is that people have used the THC potency of strains to determine superiority. Measuring potency and the effects with this method is a long-outdated classification system, especially when it does not provide accurate labels for customers and budtenders alike. The words “Indica” and “Sativa” were introduced in the 18th century to describe different species of cannabis, but modern research has led to more information that we will share throughout this article.

Historically, this is how cannabis has been defined;

Strains

Cannabis Sativa

Sativa is supposedly uplifting and cerebral, enhancing creativity and productivity. Indicas provide what has been called a “body high,” while Sativa’s deliver more of a “mind high.” Unfortunately, Sativa plants require longer to grow and yield less medicine (flowers) than Indica varieties. Sativa’s smell sweet, fruity, or spicy. This difference in the aroma results from terpenes, the molecules within the plant that are cousins to cannabinoids like THC and CBD. While these chemicals sometimes provide stunningly pungent odors, their greatest benefit to patients is their medicinal efficacy.

The problem with the general ‘idea’ of what a Sativa does, is that there is no accurate spectrum representing an understandable visual for growers and customers to understand easily.

Cannabis Indica

The typical example of Cannabis Indica is a more compact, thick-stemmed bush than its cousins, usually reaching a height of fewer than two meters. The foliage is generally a dark shade of green, some examples appearing to have almost blue or green-black leaves. These leaves are composed of short, wide blades.

Most Indicas are supposedly a rich source of the cannabinoids THC, CBD, and CBN. While Cannabis Sativa often produces a higher proportion of THC than its other cannabinoids, Cannabis Indica usually contains significant levels of all three. Indicas tend to have more body-centered effects than Sativas – enhancing physical sensations, which is not accurately measured either.

Cannabis Hybrids

Typically, a Hybrid is a cannabis plant with Indica and Sativa characteristics. Because cannabis has been cultivated for centuries, most modern strains are hybrid. Pure Sativas and pure Indicas are rare, so most cannabis you'll find these days is a hybrid.

Hybrid strains typically develop either Sativa-dominant, Indica-dominant, or evenly balanced phenotypes. Strain descriptions usually list it that way or display the split as a percentage. Remember that the terms Indica and Sativa strains are most useful for cultivators in determining growth characteristics like how tall plants will grow or how long their flowering cycle will be. Effects share no apparent connection with today's cannabis plants' physical structure, hence why the classification system is largely outdated.

So why is this a problem?

According to SC labs (SC Labs is a company that offers comprehensive solutions for cannabis and hemp testing) co-founder, Josh Wurzer;

“The problem is that there is little standardization when it comes to defining and determining terpenes”

Measuring the superiority of cannabis is confusing, and frankly, the classification system is completely outdated. It no longer only comes down to the strain. The days of just searching out the highest THC totals are rapidly receding. Research has proven that terpenes are at the base of the entourage effect, where previously, it has been considered ‘minor’ information. Cannabis growers and breeders have been assigning labels to cultivars primarily based on aroma profiles and purported effects rather than genetic ancestry or overall chemical similarity. Cultivators, processors, retailers, and consumers could benefit from greater standardization when evaluating product quality and distinguishing label claims.

Because cannabis is a widely used substance increasingly being legalized for medicinal and recreational use, Cannabis’s genetic and chemical variation must be accurately quantified and communicated. Using strain labels like Sativa and Indica are used to describe a cultivar’s morphology, aromas and/or psychoactive effects. However, whether these labels capture meaningful information about Cannabis's genetic and chemical variation is incredibly unclear. This leaves room for inaccuracy and uncertainty in a world growing in popularity faster than any other industry.

In this study, the inaccuracy of reporting is clear;

“This is consistent with previous studies indicating that cultivar names were not reliable indicators of a sample’s genetic or chemical identity”

The study shows that the genetic structure of cannabis explained only 37% of the variance in labeling, meaning that Sativa–Indica labels do not accurately reflect genetic relatedness. When the study looked at the correlation of Sativa and Indica terpenes and cannabinoids, Sativa content was positively correlated with the concentrations of bergamotene and farnesene. While on the other hand, there were significant positive correlations between Indica labeling and three sesquiterpenes: guaiol, γ-eudesmol, and β-eudesmol. This shows that it goes far beyond mere classification, and it really comes down to far more than simple labels.

The contrasting aromas that have been associated with Sativa (that is, sweet) and Indica (that is, earthy) were key discriminators in a sensory evaluation of Cannabis cultivars and mediated customers’ perceptions of potency and quality.

What is the solution?

Simple; replace the three vague classes with six elaborate and detailed classifications instead. On February 16th, – SC Laboratories, Inc., (SC Labs) announced that it has licensed Napro Research LLC’s proprietary data visualization tool PhytoFacts®. Clients testing cannabis through the lab will now have access to this game-changing reporting format and algorithm that provides a visual profile of each strain’s chemical makeup. This new report format is intuitive and helps budtenders and consumers identify the right strain for their desired effect. As mentioned above, the terpene profile proves to be far more important than the breed of cannabis, which means that companies like SC Labs are putting an end to the days of simply seeking out the highest THC percentage. Science has converged to finally prove that terpenes are at the root of the entourage effect that consumers are seeking.

Always looking to level their playing field and eliminate as much bias as possible, SC labs' owners partnered with the event organizers of Emerald Cup and NAPRO research to help reframe the conversation regarding what defines “quality” in cannabis. The Emerald Cup is widely believed to be the World Series of Cannabis competitions as it is rooted in Humboldt County. The partnership is intended to help revolutionize the collective understanding of the true role of terpene content.

The new classification system focuses on sorting flower entries by primary terpene content, leveraging a combined decade of research into Cannabis phytochemistry between  PhytoFacts® coupled with a powerful database of over 250,000 terpene tests and aggregated by SC Labs, going back to their launch of terpene testing on Cannabis in 2013 as you can see below.

What are the new classes?

‘Jacks + Haze’ Class

• Mostly ‘Sativa’-leaning varietals
• Tasting notes – Fruity, Pinesol, Haze
• Effects – Energizing, Cerebral, Artistically Inspiring
• Common Cultivars – Classic Trainwreck, Jack Herer, Durban Poison, Super Lemon Haze
• Terpenes Profile: Terpinolene, Caryophyllene, Myrcene

‘Sweets + Dreams’ Class

• Mostly ‘Indica’-leaning varietals
• Tasting Notes – Fruity, Sweet, Woody, Hoppy, Herbaceous
• Effects – Relaxation, Couch Lock, Analgesic
• Common Cultivars – Blue Dream, Tangie, Forbidden Fruit, Grandaddy Purple, Purple Urkel, Grape Ape, Cherry AK, God’s Gift, Purple Punch
• Terpenes Profile: Myrcene, Pinene, Caryophyllene

‘Tropical + Floral’ Class

• Mostly ‘Indica’-leaning varietals
• Tasting notes – Sweet, Floral, Tropical Fruit
• Effects – Calming, Soothing, Relaxing
• Common Cultivars – Super Skunk, Hawaiian, In the Pines, Dream Queen
• Terpenes Profile: Ocimene, Myrcene

‘OGs + Gas’ Class

• True ‘Hybrid’ varietals
• Tasting Notes – Gas, Fuel, Sweet, Citrus, and Pepper
• Effect – Uplifting, Stimulating, Analgesic, Relaxation
• Common Cultivars – Classic OG Kush, Chemdog, Sour Diesel, Gorilla Glue
• Terpenes Profile: Any combination or shifting codominance of Caryophyllene, Limonene, Myrcene

‘Exotics’ (Rare Terpene Combinations) Class

• True ‘Hybrid’ varietals
• Tasting notes – varied based on chemistry of entry
• Effect – varied based on chemistry of entry
• Common Cultivars – rarest terpene profiles entered into the Emerald Cup Competition

‘Desserts’ Class

• True ‘Hybrid’ varietals
• Tasting Notes – Deserts, Doughs, Citrusy & Spicy
• Effects – Stimulating, Racy, Uplifting, Comforting
• Common Cultivars – Classic Bubba Kush, GSC, Gelatos, Cakes
• Any shift in codominance of Caryophyllene & Limonene

How We’re Using The New System

Because of the reliability and shift in the right direction, Black Tie CBD has made use of the latest testing for our ‘ChemDawg’ strain, as you can see below;

As you can see from the report produced by PhytoFacts®, there’s immense detail about the aroma & flavor, identifying the spectrum of profiles in depth. The particular aroma and tastes lean far more towards earthy with some sweet and fruity profiles. Similarly, the entourage effect is highlighted, giving the budtender or end-user a clear idea of its effects. The relaxation and comfort of the strain are highlighted, with lower energy levels. The report is easy to understand and interpret, and above all the classification is distinct without being confusing.

This goes to show how important terpenes really are, and how the entourage effect varies depending on multiple facets which are not usually shown - including highlights of b-Caryophyllene (3.943 mg/g), Myrcene (3.767 mg/g), Terpinolene (2.605 mg/g). The relevance of highlighting terpenes matters significantly because terpenes have also been identified as a new frontier in cannabis medicine. Until recently, the spotlight has been focused almost exclusively on the therapeutic qualities of cannabinoids, such as THC and CBD, but as our understanding of terpenes grows more sophisticated, it’s becoming apparent that these aromatic compounds are medicinal powerhouses too.

β-Caryophyllene: β-Caryophyllene is generally the most common sesquiterpene in cannabis, and the most abundantly produced terpene in Nature. Over the last decade, it has gained scientific attention after discovering that it can directly activate cannabinoids receptors. Basically, the β-Caryophyllene terpene acts as a cannabinoid.

This is the terpene that contributes to the ever-so-slight spicy flavor, but mainly to the earthy profiles as well as the relaxation quality of this strain.

Myrcene: Myrcene is the most abundant terpene in modern commercial cannabis. Myrcene has many therapeutic benefits. Like other terpenes, myrcene is believed to have potential anti-inflammatory, potential anti-tumor, sleep-supportive, and other health benefits.

Myrcene characteristically gives our cannabis strain a mildly sweet flavor profile and provides scent notes that are spicy, earthy and muskiness - and also contributes towards that relaxing and calm effect that was mentioned.

Terpinolene: Terpinolene, a terpene dominant in about one in ten cannabis strains, is recognized for its woody smell combined with floral citrus notes. In addition to its fresh aroma, terpinolene is known for its antifungal and antibacterial properties. Terpinolene is considered more multidimensional in comparison to other cannabis terpenes.

These combined effects and profiles of terpinolene are why there are more fruity aromas and comforting effects. The combination of all three highlighted terpenes should indicate the importance of a more accurate and science-backed classification system to ensure that all effects, aromas and profiles are accounted for.

Without having to handle the substance, users and budtenders can now have a true discourse about the desired flavor, fragrance, and potential effects of cannabis. Consumers may now finally buy cannabis online with ease thanks to the new classification system and PhytoFact® information.

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Buying a CBD tincture can be an overwhelming process, especially when you’re faced with so many factors, like potency, spectrums, price, cannabinoids, and other considerations. Here at Black Tie CBD, we want to simplify the process and give you all the information that you need to make a confident decision in your purchase. We will be covering everything that you need to know.

Firstly, it’s important to highlight the spectrums and the purposes that they serve, so you know which one is best suited for your needs. The spectrum term indicates the number of other substances present in the CBD itself.  Even in plants containing very little THC (the psychoactive substance found in cannabis), there are many other chemicals present. These are other cannabinoids, terpenes, and flavonoids.

Full Spectrum vs Broad Spectrum:

If you are a user of CBD, then you have more than likely stumbled across terms such as “full-spectrum” or “broad spectrum”. The main difference between full-spectrum and broad-spectrum CBD is the compounds they contain.

If a CBD product contains several naturally occurring cannabis plant extracts, such as terpenes and other cannabinoids — including up to 0.3% THC — it is full-spectrum CBD.

Broad-spectrum CBD also contains several cannabis plant compounds, but it is typically entirely free of THC. All of the broad-spectrum items on BlackTieCBD.Net are completely THC Free.

Full Spectrum CBD:

Full Spectrum CBD contains the most naturally occurring extracts. This includes a small amount of THC (less than 0.3% THC Delta-9). There is certain scientific evidence of an ‘entourage effect’ – a positive response to the presence of various terpenes in CBD. Taking the full spectrum of terpenes, flavonoids, cannabinoids, fatty acids and trace THC is regarded by some scientists as the most effective way for the entourage effect to work.

Due to the “entourage effect”, full-spectrum CBD is believed to last longer and have more powerful effects than broad-spectrum or CBD isolate

Broad Spectrum CBD:

Broad-spectrum CBD oil is a middle ground between CBD isolate and full-spectrum CBD oils. It has all of the cannabinoids and other chemical compounds except for THC. It has all the beneficial chemical compounds except for THC, so you’re likely to gain some of the beneficial effects of the entourage effect.

Broad-spectrum also goes through the normal extraction process. For places where THC is illegal, the benefit of broad-spectrum CBD oil is that in the final stages of processing, the THC is removed from the extract. Therefore, broad-spectrum CBD oil will not show up on a drug test if the test is looking for THC.

If you're looking for a health boost from CBD but want to skip the THC effects, broad-spectrum is probably your best bet. If you don't mind THC and want to potentially get more benefits out of your CBD product, full-spectrum is probably the way to go.

Potency:

Now that you know which spectrum to choose, it all comes down to choosing the correct strength and potency. When searching for products, you’ll come across a lot of different strengths (potencies). You’ll find ranges from 300 mg to 4000mg per bottle. With so many CBD options to choose from it can make you feel like you have no idea what you’re even looking at. So let’s simplify it;

CBD potency specifically refers to how strong it is. On CBD oil labels, look for the milligrams per milliliter (mg/mL) - that’s what determines the product’s concentration of CBD. If a CBD extract is rated at 300mg, it’s going to be about half as strong (potent) as the same amount of a CBD extract rated at 600mg CBD. But, it also depends on the size of the bottle.

Here is another example where the bottle size is significant. Suppose there are two bottles of CBD oil; both have 300mg of CBD. However, one bottle contains 15ml of liquid, while the other has 30ml. In this case, the smaller 15ml bottle’s CBD concentration is double that of its 30ml counterpart with 20mg of CBD per ml against 10mg.

How to measure your dose:

A single dose of CBD Oil to be .5mL, and depending on the product, this can be easily measured using the marked dropper under the top.

To simplify it further, A 30ml bottle will contain 60 dosages within. If the potency of the bottle is 1200mg, each dose contains 20mg of CBD, while a 15ml bottle will contain 30 dosages within. If the potency of the bottle is 1200mg, each dose contains 40mg of CBD. This should act as your guideline when choosing your dosage, and fortunately we released our tinctures in these specifications to make it easier for our customers.

For example:

Low-potency CBD oil (300 mg)

This is a relatively low-potency oil and is a good option for individuals who are just starting out or who may be sensitive to CBD. A low-strength 300 mg bottle is a good option to take as a daily supplement. Many people take a single daily dose of it for boosted general health, and also to help lower stress levels.

Mid-Potency CBD Oil (600mg)

A 600 mg CBD oil is a good “step-up” option for people who find they’re having to take large (and/or multiple) doses of lower potency. In general, a lot of people use products in this strength range for things like anxiety and day-to-day pain.

High-Potency CBD Oil (1200mg +)

The 1,000 mg range is closing in on the higher end of the potency scale, but some bottles could range to 5000mg and above, with the intention of higher potency in fewer drops. Products in this strength range are commonly used for sleep issues, deep muscle soreness, migraines, and day-to-day stress and anxiety.

So, which one should you choose? As much as we would love to answer that for you, each person is different. A great way to make your choice is to ask yourself why you want to take CBD in the first place and assess which potencies are typically used for those reasons.

Another aspect to consider that not many people pay attention to, but should, is the Cannabinoid used or the combination thereof.

Cannabinoids and combinations:

Cannabinoids are like a buffet to choose from. Choose the ailments you suffer from, and select the product that contains the helpful cannabinoid compounds that work best for you. Most people select CBD as it is the most popular and widely known cannabinoid, which doesn’t necessarily mean that it is the answer to all of your needs.

CBD:

CBD is generally great for overall well-being. It is suitable for general ailments and issues that you might be facing in your life. Over the last few years, CBD has become the cannabinoid of choice, not only for the many therapeutic benefits it offers, but also because it has no psychoactive properties. Unlike THC, CBD offers pain relief and other benefits without the risk of paranoia, anxiety, or impaired cognitive function.

This means that CBD is great for people wanting to target a number of ailments and use it for general health purposes.

CBG:

CBG interacts with the body in a different way. This means it has different effects than CBD does.  It is thought that CBG has a calming effect on the body, causing a relaxation of the nerves. There are technical terms for such changes, for example, inhibition of the sympathetic nervous system but rather than be blinded by complex medical terms it is easier to think of CBG as having a nice calming effect. CBG also appears to increase the levels of our natural, in-built cannabinoid called anandamide. This wonderful endogenous cannabinoid quite simply makes us feel good.

This means that CBG is most suitable for people striving for that ‘feel good’ feeling, or the general serenity within the body.

Delta-8:

Like delta-9 THC, delta-8 produces feelings of euphoria, relaxation, and potential pain relief, but they’re a lot milder. For people who don’t want to experience a pronounced “high,” the lower potency may be a benefit. Because of this, Delta 8 can be used to treat a wider range of cancer patients, such as those who won’t use Delta 9 THC because of the anxiety feeling they receive when they take it.

This makes Delta-8 a great sedative and the perfect candidate for people dealing with more intense ailments, but still offers a wide use for overall well-being, too.

With all of that being said, choosing your tincture comes down to three main factors; Spectrum, potency and strength, and finally the cannabinoid or combination of cannabinoids. From this, you should be able to understand and choose the product that best suits your needs. At first glance, it seems to be an overwhelming process, but really it’s quite simple.

Have a look at our selection of tinctures for one that best suits your needs.

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The cannabis plant is home to over 200 cannabinoids and terpenes that have potential health benefits. Following the wild success of delta 8 THC as a legal alternative to the more controlled availability of delta 9 THC, the cannabis industry has sought other less-known cannabinoids to compete in the diverse cannabis marketplace. One of the newest, semi-synthetic cannabinoids called hexahydrocannabinol, usually shortened to HHC.

Hexahydrocannabinol (HHC) is a cannabinoid that was first discovered in the mid-1940s. In 1944, the American chemist Roger Adams created HHC when he added hydrogen molecules to Delta-9 THC. This process is known as "hydrogenation." HHC is found in limited quantities in the hemp plant. Although HHC is a naturally occurring compound, it is hard to obtain sufficient amounts to make products. But by certain production processes, companies can convert CBD into HHC to make a wide variety of products.

While HHC has been around for years, it has not been often discussed by cannabis users until recently.. HHC is a minor cannabinoid; it occurs naturally in cannabis, but in amounts too small to make extraction cost-effective - this means that for companies to sell this cannabinoid, they’re going to need to make it in a lab. HHC does, however, have one major legal advantage over delta 8 and delta 10: it isn’t THC.

So how is HHC made?

As mentioned above, Roger Adams is the first person to discover HHC using the process known as ‘hydrogenation’. There are a couple of different methodologies to hydrogenate delta-8 into HHC, but Hydrogenation is simply treating a compound with hydrogen, which causes a chemical reaction between hydrogen and another compound or element, usually in the presence of a catalyst such as nickel, palladium, or platinum. This is done in order to reduce or saturate organic compounds.

Adams originally applied this technique to THC derived from marijuana plants, but since the 2018 Farm Bill came into effect, legalizing cannabis crops with less than 0.3% delta-9 THC, more manufacturers are applying the hydrogenation of cannabinoids to CBD to produce HHC.

When it comes to HHC specifically, Hydrogenation modifies the structure of delta 9 THC by replacing a double bond with two hydrogen atoms, which changes its molecular weight and makes it more stable. According to chemist Mark Scialdone;

“A major benefit to hydrogenation is that it offers stability at the molecular level, assisting with both shelf life, and resistance to heat.”

It should be said, though, that the acronym “HHC'' is also used in scientific literature to refer to dangerous synthetic substances like 9-Nor-9β-hydroxyhexahydrocannabinol and 11-Nor-9β-hydroxyhexahydrocannabinol. All those Greek letters and super-long hyphenated chemical names are surefire signs that these forms of HHC are synthetic.

What Are The Effects Of HHC?

First, it’s important to note the different types of HHC that are available on the market. There are at least 10 types of HHC:

1. HHC — Hexahydrocannabinol (CAS# 6692-85-9)
2. 7-OH-HHC — 7-hydroxyhexahydrocannabinol (CAS 64663-39-4)
3. 8-OH-iso-HHC — 8-hydroxy-iso-hexahydrocannabinol (No CAS#)
4. 9α-OH-HHC — 9α-hydroxyhexahydrocannabinol (CAS# 52171-85-4)
5. 7-9α-OH-HHC — 7-oxo-9α-hydroxyhexahydrocannabinol (No CAS#)
6. 10α-OH-HHC — 10α-hydroxyhexahydrocannabinol (No CAS#)
7. 10α-ROH-HHC — 10aR-hydroxyhexahydrocannabinol (No CAS#)
8. HU211 — 1,1-Dimethylheptyl-11-hydroxytetrahydrocannabinol (CAS 112924-45-5)
9. HU243 — 11-Hydroxy-3-(1′,1′-dimethylheptyl)hexahydrocannabinol (CAS 140835-14-9)
10. HDHHC — 3-Dimethylheptyl-11-hydroxyhexahydrocannabinol (CAS 140835-18-3)

HHC has very similar effects to delta-9 THC—it's a psychotropic compound that produces feelings of euphoria, changes in perception, altered cognition, as well as other potential properties. When it takes on other forms, it becomes slightly more complicated. Many users report the effects of HHC are similar to that of delta 8 THC in terms of being more heavily weighted towards relaxation than stimulation. HHC is more potent than delta 8 but slightly less potent than delta 9 THC.

We've seen a sudden ride of THC isomers—variants of the notorious delta-9 THC molecule, as people look for a legal means to experience the intoxicating effects of marijuana. Popular THC cannabinoid analog isomers include delta-8 THC and delta-10 THC derived from hemp crops. Although HHC isn’t technically a THC, it does produce similar effects—if you use enough of it. When it’s produced in the lab, an HHC batch is a mix of active and inactive HHC molecules. The active HHC binds well with your body’s cannabinoid receptors; the others don’t.

A study published in 2010 found that HHC’s effects lasted a long time in rats. Overall, apart from the limited research outlined in this section, there is nothing else to link HHC with the benefits claimed by manufacturers. Certainly, there are no studies on humans that provide any insight.

Is HHC Legal?

Although HHC is not the same as THC, it is potentially illegal if deemed synthetic. The FDA’s Interim Final Rule (IFR) states that synthetic cannabinoids in hemp are illegal, while naturally-occurring ones are permitted. It is true that HHC occurs naturally in hemp and cannabis but only in tiny amounts. HHC manufacturers make it in a lab via a chemical process designed to create more of it.

With the rise of delta 8, hexahydrocannabinol was recognized as yet another form of “legal THC” capable of being sold to the masses. No matter how much marketing material you read, however, delta 8 and HHC will never be equitable. One is a synthetically derived cannabinoid while the other is a natural substance.

We wouldn’t be surprised if HHC starts getting attention from the DEA, as we suspect that considering the need to synthetically create it - HHC falls under the Federal Analogue Act, which automatically classifies analogs of Schedule 1 drugs as Schedule 1 drugs themselves. If the DEA agrees, HHC could have a very short market span.

Is HHC Safe?

As it stands, HHC is rarer and more difficult to derive than delta 8, the HHC market is smaller and less competitive, resulting in comparatively inferior products. Because hexahydrocannabinol (HHC) is still very new, there aren't very many studies available that investigate its potential effects and safety - which is enough to tell us that as it stands, it is not particularly safe.

With the limited research on HHC, we highly suggest that you stick to the better known cannabinoids with ample research surrounding it like CBDV which we have done extensive research into and offer safe, legal products containing this cannabinoid.

HHC seems to be following a very similar and dangerous route to THCO, another synthetic cannabinoid taking the industry by storm. We can only hope that the search for something stronger and different does not take priority over the search for something more beneficial and well-researched.

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With Covid-19 impacting us for the last two years, the world is rapidly searching for ways that we can effectively manage the virus, despite the variants that constantly pop up. Finally, it seems that research is progressing and it’s the cannabis industry at the forefront of the latest research advancements by researchers affiliated with Oregon State University. These researchers conducted a study that suggests that cannabis compounds prevent Infection by the Covid-19 Virus.

The COVID-19 pandemic includes at least 272 million cases worldwide, 5.3 million deaths, and over 600 000 new cases daily. While the rollout of vaccines is underway, the rapid spread of COVID-19 underscores the need for new treatments.

Background Information:

In January 2021, this study looked into the possibility that cannabis may offer some help for patients with COVID-19. The study looks at one of the primary biological events that occur in patients with severe acute respiratory distress cases from COVID-19, something called a “cytokine storm.”

C.Sativa, a type of cannabis, was found in a cytokine storm study to reduce multiple cytokines and pathways related to inflammation and fibrosis. Two of the cytokines that C.Sativa reduced were TNFa and IL-6, which are thought to be the main targets when trying to block a COVID-19 cytokine storm and acute respiratory distress syndrome.

In another study done in September of 2020 on mice, they found the following;

“Several reports demonstrated that cannabidiol (CBD), a phytocannabinoid produced by the cannabis plant, can block IL-6 in several models of inflammatory diseases.”

What do the studies say in 2022?

A report on the research, “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants,” was published online on January 10th, 2022 by the Journal of Natural Products.

COVID-19 is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Researchers have found that the viral spike protein of SARS-CoV-2 to the human cell surface receptor angiotensin converting enzyme-2 (ACE2) is a critical step during the infection of human cells. The researchers looked into the following possibility:

“Therefore, cell entry inhibitors could be used to prevent SARS-CoV-2 infection as well as to shorten the course of COVID-19 infections by preventing virus particles from infecting human cells.”

Researchers discovered that cannabinoids increase the cell’s response to several key proteins produced by the coronavirus genome, which is an effect that had not been discovered prior to the study. Researchers also looked at how the proteins from the genome operated in human kidney cells and healthy control cells, both with and without cannabinoids.

Cannabis and its effectiveness against new variants:

The spike protein is the same part of the virus targeted by Covid-19 vaccines and antibody therapies. In addition to the spike protein, SARS-CoV-2 has three more structural proteins as well as 16 nonstructural proteins and several compounds van Breemen characterized as “accessory” proteins, all of which are potential targets for drugs developed to prevent Covid-19.

The two compounds commonly found in hemp - called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA - were identified during a chemical screening effort as having potential to combat coronavirus. In the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, they found that cannabinoids bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people, stating that;

“Cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells”

This means that cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.

The study then goes on to state that the most important piece of evidence found was that CBGA and CBDA were equally as effective against the alpha and beta variants. The abstract ends off on a highly positive note, expressing that cannabinoids do in fact have the potential to prevent and likely treat infection by SARS-CoV-2.

What other benefits could cannabis pose for Covid-19?

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1. Anxiety
   The number of people reporting high levels of anxiety has sharply elevated during the coronavirus (COVID-19) pandemic. The factors most strongly associated with high anxiety during the pandemic include loneliness, marital status, sex, disability, whether someone feels safe at home or not and work being affected by the coronavirus (COVID-19) pandemic.
   
   There is understandable concern about the impact of the pandemic on people’s well-being. Fortunately, though, compounds within cannabis have shown impressive anxiety-reducing qualities, particularly CBD, which has been shown in studies to increase serotonin activity and lower cortisol levels.

Is Cannabis safe to consume for Covid-19 patients?

While most people consume cannabis by smoking it, it is not the only way to consume it. Companies like ourselves offer multiple variations of consumption like edibles, tinctures and more that have very low THC, yet still offer the same benefits.

After the last two years of uncertainty, illness and chaos due to the pandemic, it’s relieving to see that cannabis has shown a lot of potential in fighting against COVID-19 and could potentially offer new solutions to tackle the pandemic.

Where can you get CBDA and CBGA products from?

The team here at Black Tie CBD is relieved and grateful that we’re a part of an industry that is helping to better global health in such an impactful way. As a company, we've seen the value in CBDA products and we've just released our brand new CBDA isolate so you can keep safe too.

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With countries worldwide slowly legalizing cannabis, research is finally growing and we’re constantly finding out more about the 120+ cannabinoids in the marijuana plant, namely CBDV, otherwise known as Cannabidivarin. 

People are looking beyond conventional THC or CBD and seeking out new cannabinoids like this one, and in this article, we will explain why CBDV is worth looking into. The laws have limited public access and therapeutic research on non-psychoactive cannabinoids. Fortunately, we’re discovering more and more cannabinoids that are non-psychoactive and still have the healing properties of cannabis.

So, what is CBDV?

Cannabidivarin (CBDV) is a Varin cannabinoid first reported in a benzene extract from a Thai cannabis variety referred to as “Meao” in 1977, and identified for the first time in 1969 Vollner et al. CBDV is a homolog of CBD and is a non-psychoactive cannabinoid. As you can see below, The slight difference here is the propyl chain that CBDV carries. 

Like CBD, cannabidivarin has 7 double bond isomers and 30 stereoisomers. There is a side-chain shortened by two methylene bridges. The biggest difference between CBD and CBDV is their concentrations in the cannabis plant. You can find trace amounts of CBDV in high-quality full-spectrum and broad-spectrum extracts that help to produce the entourage effect.

Varin cannabinoids (technically called varinolic cannabinoids) are a subfamily of cannabinoids that feature three carbons on their alkyl side chains. The most well-known examples are THCV, CBDV, CBGV, and CBCV. There are also acid forms of THCVA, CBDVA, CBGVA, and CBCVA.

CBDV exists in very small quantities. Recently, several African landrace strains (which are genetically pure and unimpacted by experimentation) of Cannabis indica were found to have CBDV and the related THCV in concentrations closer to 4%. There are also plant breeders creating high CBDV and THCV strains of hemp and marijuana — but the current record still sits below 7% CBDV. 

What are the medicinal effects?

Epilepsy

Due to the rise in popularity of CBDV, researchers are trying to discover its medical benefits. In 2014, GW Pharmaceuticals finished a Phase 1 clinical trial of its CBDV test product (known as GWP42006). The clinical trial explored the use of CBDV as an anti-epileptic drug. The company continues to research CBDV heavily. You won’t feel a psychoactive ‘high’ from CBDV. Instead, you can expect it similar effects to CBD. The lack of a ‘high’ means we can use CBDV similarly, which is still being researched.

GW were set to enter Phase III trials in late 2019 but had to terminate the study because of the pandemic. They’re currently recruiting for a new trial, and the CEO Justin Gover made the following statement;

“CBDV represents an additional product pipeline opportunity as a next-generation epilepsy therapy.”

This study follows the completion of a Phase 1 trial in 66 healthy subjects in 2014. In this trial, CBDV was well tolerated even at the highest tested dose and no significant side effects were observed. Most importantly, following this trial, There were no serious or severe adverse events, nor any withdrawals due to adverse events.

Rett Syndrome

As you may know, Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioral and physiological symptoms with no cure available to date. A study was done on mice with CBDV being administered for 14 days. The study restored compromised general health status of the mice, the sociability, and the brain weight in RTT. While more studies are required, this shows great promise for the medical use of CBDV.

Autism

Some of the most interesting recent research into CBDV has been around the subject of autism. This condition, which affects more children and adults every year, is still being researched to find effective medications. The use of CBDV for autism has rapidly gained popularity over the last two years.

The study suggests that CBDV targets subcortical excitatory glutamate systems both in autistic and neurotypical adults. This study compared the effects of CBDV in neurodiverse patients and neurotypical patients. They noted a higher degree of difference in ASD patients with elevated glutamate. Very little benefit was reported on those with normal glutamate levels.

Some studies have even shown that people diagnosed with autism spectrum disorder (ASD) have below-average anandamide levels in the brain, one of the body’s endocannabinoids. 

Pain

In this study, patients underwent two successive treatment phases (4 weeks each) and were treated with CBDV. While the study wasn’t necessarily conclusive, it did explore the potential utility of CBDV for neuropathic pain. 

While CBDV research is increasing, so far there are no guarantees that cures or applications have been or will be found. The existing CBDV studies and research papers indicate grounds for medical optimism that previously may not have existed. With the growing interest in the industry, there’s endless potential. Fortunately, there should not be severe restrictions on CBDV, considering its lack of psycho-activity. 

CBDV and the endocannabinoid system:

CBDV interacts with the endocannabinoid system (ECS) the same way as CBD. However, it’s thought to have about 25% of CBD potency. CBDV does not stimulate the ECS as CBD and THC do; it has a modulating action instead. According to the British Pharmacological Society;

“CBDV and all the acids inhibited DAGLα.”

DAGLα is an enzyme responsible for the synthesis of the endocannabinoid 2-AG.

Is CBDV Legal? 

CBDV is legal in the United States, as long as it is produced from Hemp rather than marijuana. This is because CBDV derived from marijuana is illegal on a federal level and is considered a schedule 1 drug by the Drug Enforcement Agency (DEA). Some states have legalized marijuana for medicinal or recreational use. The states that have legalized marijuana have also legalized its derivatives, including CBDV. 

CBDV derived from hemp containing no more than 0.3 percent THC is considered legal on a federal level due to the 2018 Farm Bill. This Bill gave states the power to further regulate hemp products, which some states have by restricting any traces of THC. Although hemp-derived CBDV is difficult to find, it’s legal in all states as long as it abides by the state THC regulations. 

What is the difference between CBDV and CBD?

As previously mentioned, the molecular structures between CBD and CBDV are different, which impacts their chemical responses. Furthermore, CBDV can be used to develop THCV (tetrahydrocannabivarin) when it’s exposed to an acidic environment. CBD doesn’t have this same ability to transform into THC. When dealing with CBDV vs CBD, both cannabinoids share huge similarities that could be a massive hit in the medical industry because of the therapeutic effects offered. Above all, CBD and CBDV both interact with the endocannabinoid system, but CBDV binds with the cannabinoid receptors and CBD simply interacts or blocks the receptors.

Based on all the information provided, it’s clear why Cannabidivarin might be the next significant cannabinoid the world will witness, and we can only hope that research increases to increase the use of CBDV globally.

As many of you know, curing and drying are processes that can significantly impact the taste and general quality of your cannabis crop. Properly drying and curing your fresh cannabis stash is paramount to prevent harsh smoke and prevent mold contamination from taking place.

Harvesting your cannabis is only half the work. Post harvest operations are arguably just as important as pre-harvest. Many believe that curing and drying are the same things, which they aren’t. Black Tie CBD has been asked why we haven’t released our 2021 strains, and the answer is simple; we believe in a low and slow curing process that ensures quality to the end product that we offer you.

Below, we’ll share our answers to some frequently asked questions on the drying and curing processes, so you can maximize the flavor and potency of your stash - as well as better understand how post-harvest processes are done correctly.

The importance of drying cannabis

Freshly harvested cannabis buds contain significant moisture, which needs to be dealt with before smoking. Essentially, drying also converts THC from its non-psychoactive, crude, acidic form to its psychoactive neutral form.

Cannabis flowers are full of active components; The resin glands contain THC, CBD and other cannabinoids. The issue is that when your plants are recently harvested, they’re still quite green and most of the THC is inactive. Drying marijuana means reducing the water content of the buds to 10-15%, depending on the desired crispiness of the final product.

A dry shouldn’t be too quick or the outside of buds will appear dry but the insides won’t be, leaving chlorophyll within; too long, and buds could develop mold.

How do you dry cannabis?

The drying procedure usually depends on the trimming process that you use;

• Dry trimming
• If you’re trimming plants after they’ve been dried, then you’ll be able to hang them from a line or hanger. Hanging is preferable as it prevents buds from becoming misshapen. To test if the plants are ready for trimming, you can try bending a branch. If it bends, it needs more drying. If it snaps, it is ready for trimming and curing.

• Wet trimming
• If you trim the plants before drying, you’ll have smaller plant parts to dry and need to use a rack. You can check when buds are ready for curing by squeezing them. If they still feel wet or moist, they likely need more time before moving on to curing.

Dying cannabis involves focusing on:

• The drying method used.
• Temperature.
• Moisture levels.

What are the drying methods?

Hang Drying Cannabis

Hang drying is a cost-effective solution for cannabis cultivators with a limited budget and involves exposing your cannabis to the open air. To hang-dry your cannabis, your branches are hung upside down from an elevated position and dried. You must regularly monitor the temperature and airflow of the room for the best results.

Choosing a cool, dark place to dry your buds is essential. Ensure that your flowers are spaced adequately for airflow to carry moisture particles away without attracting mold. Hang-drying is great, but requires a lot of environmentally controlled space.

This process usually takes anywhere from 1-2 weeks.

Using a drying rack

When preparing cannabis for commercial purposes, trimming machines are usually used, so this method is ideal. A drying rack is great for keeping the yield organized, and there is far lower risk of contamination or mold. While this option is more pricey, it is the ideal piece of equipment when it comes to drying weed correctly. Using a drying rack with a large surface area for the buds allows for more airflow, meaning that the moisture is taken away in far less time.

Again, this is a process that takes upwards of 10 days. If the snapping sound of your bud is crispy and sharp, then you know that your weed has been dried properly.

While you may be looking for a faster drying process, If buds are dried too quickly, chlorophyll and other pigments, starch, and nitrates are trapped within plant tissue, making it taste “green,” burn unevenly and taste bad. However, slowly dried buds taste sweet and smoke smooth. Taste and aroma improve when pigments break down. Slow even drying–where moisture content is the same throughout stems, foliage and buds– allows enough time for the pigments to degrade.

How to perfect the drying process:

As stated above, we focus on a slow drying process. We hang entire plants to dry; allowing the process to take place over time. We remove large leaves and stems (fan leaves) in the field as fresh leaves are easier to work with. The plants are then hung until they reach an ideal moisture content. At that point they buds are hand-trimmed and placed into curing.

Temperature:

We place importance on circulation and ventilation as this helps us control the heat and humidity of the room. The ideal air temperature is between 65 and 75°F (18-24°C), and humidity from 45-55%. Any temperatures lower may slow drying and increase the threat of harsh smoke, and any temperatures higher may cause the buds to mold.

Similarly, any lower than suggested humidity causes a speedy dry period, causing the retention of chlorophyll and giving the weed a terrible taste and odor.  The most important thing to note is that different climates are required for growing cannabis and drying it.

Hanging:

Due to the quantity of cannabis that we dry, we use a large space for drying. It is ideal to cut the plants at the base and remove the large leaves - then hang them on the drying lines in the drying facility. Branches should be cut from 12-40 inches, with each branch manicured and hung.

Manicured branches should be hung to dry for a few days before being bucked from the stem and placed on drying screens to allow the bulk of the moisture to dissipate. Once it is all on screens, the buds should be turned daily to ensure even drying. It is also adequate for manicured buds to be placed in boxes to dry, but the drying pace is slower due to the limited airflow.

Drying time:

Drying can take between five to seven days depending on temperature, humidity and bud density. The larger, denser buds can take around four days longer, so it’s important to check your buds to determine the proper moisture content. If you want to check the readiness, bend the stem and ensure that it snaps rather than folds; this generally indicates that it is ready to cure.

The importance of curing cannabis:

The curing process is possibly the most overlooked aspect of producing cannabis. During curing, moisture continues to draw from the center of the bud toward the outside.

Curing your bud is similar to the aging process of products like wine and cheese. Instead of a fermentation process, the main focus is on humidity with curing weed. Because even-though most moisture has evaporated and left the cannabis during the drying of the plants, there’s still some moisture left in the weed. Any friction and rough handling of the buds will knock off valuable resin glands and diminish the cannabinoid content.

The first week of curing affects potency as it evenly removes moisture within the bud so virtually all the THC is psychoactive, which is what most people are after. Curing also allows buds to dry enough that mold does not grow when buds are stored. Well-cured buds have an even glow when burned and smoke smooth. It is essentially not enough to simply keep your weed in a jar and say that it’s been correctly cured.

The process of curing cannabis:

The first step to curing your cannabis is to cut the stems into lengths less than 30-45 cm and then place them into an airtight container, ideally with a rubber seal. Any Ziploc or plastic bags are not ideal - some growers say that plastic imparts an undesirable flavor on the buds and is not impervious to oxygen.

Once the buds are enclosed, a microclimate is created, and the buds get an even spread of moisture. Once the buds are enclosed, they should be stored in a cool, dry, and dark place. Check on your buds at least once per day for two weeks. Use a hygrometer to check relative moisture in the container during the curing process. If you don’t have a hygrometer handy, you can gently squeeze to feel if they are moister than before.

During this check-up, keep your jars open to allow for air exchange, and inspect each bud individually for signs of mold. If you find an infected bud, make sure to remove it from its jar immediately to avoid the fungus spreading. If buds are sticking together in clumps when you try to shake the container, it means they still have too much moisture and need to be dried further.

Ideal conditions for drying cannabis:

Humidity

You want to stabilize the relative humidity at around 45-55% when the buds are placed in an enclosed container. This is the correct environment to cure your cannabis buds to perfection.

Temperature

65-75

Light

None

If buds are too dry:

leave them in the container and let excess moisture escape out the top by opening the container for a few minutes every few hours before closing the lid again.

If buds are too moist:

If you live in a normal to dry climate, you may be able to get away with just leaving the top off the jars for 1-4 hours. If you live in a humid climate, you may have to take the buds out of the jars and lay them out until the outsides begin to feel dry again.

The curing process is most important during the first two weeks and can take over six months for the highest quality outcome. It’s clear that this process is incredibly long when done correctly, which is why we release our new strains later than most other companies. We place the utmost importance on a long process that ensures the highest quality outcome.

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